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Completed

NCT Number: NCT01257295

Properties of Dietary Fibre and Energy Intake

Dietary fibers likely have a role in body weight management. They may increase satiety and, as a consequence, reduce energy intake during the next meal. There are, however, many different types of dietary fiber, which have diverse physical properties and can therefore impact these outcomes differently. It is, however, unclear whether dietary fibers with different properties lead to differences in energy intake during the next meal. The objective of this study is to study the effect of pectin in 4 different physicochemical states on ad libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal hormones, gastric emptying rate, feelings of satiety and the method of fiber supplementation. We hypothesize that viscous and gelling fibers will reduce ad libitum energy intake compared to low viscous and low gelling fibers.

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Key information

Conditions

Healthy Male Subjects

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Wageningen University

Wageningen, 6702, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-30 year
  • BMI 18.5-25 kg/m2
  • Healthy as judged by the participant

Exclusion criteria

  • Females
  • Weight loss or weight gain of more than 5 kg during the last 2 months
  • Using an energy restricted diet during the last 2 months
  • Lack of appetite for any reason
  • Restrained eater: >2.89, measured by DEBQ (35).
  • Smoking
  • Heavy alcohol use: >5 drinks/day (36).
  • Reported stomach or bowel disease
  • Reported diabetes
  • Reported thyroid disease or any other endocrine disorder
  • Reported intolerance for pectin, bread, gluten, dairy or not liking of the research foods
  • Anemia: Hb<8.0 mmol/l
  • Fasting glucose levels >5.8 mmol/l
  • Blood donation from 6 weeks prior to the study until the end of the study
  • Experienced any problems with drawing blood in the past
  • Antecubital veins not considered suitable for blood drawing by means of a catheter
  • Thesis students or employees of the division of Human Nutrition

Treatment and study plan

control: no fiber addition

Dietary Supplement

liquid breakfast without addition of fiber

breakfast with low viscous, low gelling pectin

Dietary Supplement

10g of low viscous, low gelling pectin dissolved in a liquid breakfast

high viscous, low gelling pectin

Dietary Supplement

10g of high viscous, low gelling pectin dissolved in a liquid breakfast

low viscous, high gelling pectin

Dietary Supplement

10g of low viscous, high gelling pectin dissolved in a liquid breakfast

high viscous, high gelling pectin

Dietary Supplement

10g of high viscous, high gelling pectin dissolved in a liquid breakfast

pectin supplement

Dietary Supplement

10g of high viscous, high gelling pectin provided as a dietary supplement, a liquid breakfast is served seperately

Primary outcomes

  1. energy intake

    Time frame: 3 hours

    3 hours after ingesting the test breakfast ad libitum energy intake is measured.

Secondary outcomes

  1. appetite sensations

    Time frame: 3 hours

    appetite is measured by VAS scales over a period of 3 hours after ingestion of a test breakfast

  2. satiety hormones

    Time frame: 3 hours

    satiety hormones (ghrelin, PYY, GLP-1, CCK) are measured over a period of 3 hours after ingestion of a test breakfast

  3. gastric emptying rate

    Time frame: 3 hours

    gastric emptying rate is measured over a period of 3 hours after ingestion of a test breakfast

  4. method of supplementation

    Time frame: 3 hours

    One of the fibers will be offered as tablets that will be ingested with a glass of water right after the test meal.

Sponsors and collaborators

Lead sponsor

Wageningen University

Other

Registry information

Official study title

Properties of Dietary Fibre and Energy Intake: an Intervention to Study the Effect of Physicochemical Properties of Dietary Fibre on Energy Intake and Underlying Mechanisms

Acronym: ProVe

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Dec 9, 2010
Registry last updated
Dec 26, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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