Proof of Concept for Simulating Static Weight-bearing Exercises in the Supine Position

This project evaluates a new weight-bearing CT method to later improve early detection of implant migration after knee arthroplasty.

This method aims to allow patients to apply a controlled load during CT scanning, simulating standing conditions with real-time feedback.

The study has two phases. First, in healthy volunteers, biomechanical loading during prone simulated weight-bearing will be compared with a standard standing squat to validate the method. Second, in arthroplasty patients, standard radiographs will be compared with loaded and unloaded WBCT scans.

Patients will not deviate from the standard plan of care. The CT images are additions to the standard RX images and are not intended for diagnostic purposes to the patient.

The aim is to determine whether this method opens the door for more accurate and earlier detection of implant migration than current clinical imaging in the future, potentially improving long-term outcomes after knee arthroplasty.

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Key information

Conditions

Knee Arthroplasty, Total Healthy Participants

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy participants
Patients with TKA

Exclusion criteria

neurological conditions
acute trauma

Treatment and study plan

Static supine weight bearing CT

Diagnostic Test

Static supine weight bearing CT in addition to standard care RX

Primary outcomes

Validation of static supine weight bearing against standing weight bearing using kinematic parameters

Time frame: 1 year

Comparison of lower-limb and trunk joint kinematics between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using marker-based motion capture.

Unit of Measure: Degrees (°)
Validation of static supine weight bearing against standing weight bearing using kinetic parameters

Time frame: 1 Year

Comparison of ground reaction forces and joint moments between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using force plate measurements.

Unit of Measure: Newtons (N) and Newton-meters (Nm)
Validation of static supine weight bearing against standing weight bearing using muscle activation

Time frame: 1 year

Comparison of lower-limb muscle activation patterns between static supine weight-bearing and standing weight-bearing conditions in healthy subjects using surface electromyography.

Unit of Measure: Percentage of maximum voluntary contraction (%MVC)

Study contacts

Contact information is provided by the study sponsor or research team.

Nicolas Van Vlasselaer, Master

CONTACT

[email protected]

555-5555

Sponsors and collaborators

Lead sponsor

Vrije Universiteit Brussel

Other

Registry information

Official study title

Validation and Evaluation of a Static Supine Weight-Bearing Computed Tomography Method to Enable Detection of Implant Migration After Knee Arthroplasty

Acronym: SWB_PoC

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: May 7, 2026
Registry last updated: May 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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