Prone Position During ECMO in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Hypoxaemic Patient

Introduction:

The main manifestation of COVID-19 pneumonia is acute respiratory distress syndrome (ARDS), which in some cases can be more severe than intubation, extracorporeal membrane venous oxygenation (VV-ECMO) to ensure hematosis. Despite support from VV-ECMO, some patients may remain hypoxemic. One possible therapeutic procedure for these patients is the application of the prone position.

Objective:

The main aim of this study was to investigate the modification of the PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO with refractory hypoxemia. The secondary objective was to evaluate the safety and feasibility of the inclined position for ECMO.

Methods:

the investigators reviewed the electronic records and lists of all 23 COVID-19 patients. were placed for the first time in PP with an average duration of 16 h . patient characteristics, pre-ECMO characteristics, ventilator/ECMO settings, and changes in ventilator/ECMO settings and blood gas analysis before and after PP.

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Key information

Conditions

SARS CoV 2 Infection Behavior COVID-19 Coronaviridae Infections Coronavirus Infections Health Behavior Hypoxemic Respiratory Failure Infections Lung Diseases Nidovirales Infections Patient Acceptance of Health Care Patient Compliance Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases Respiratory Tract Infections Treatment Adherence and Compliance Virus Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

younes Oujidi

Berkane, 9999, Morocco

About this study

The main objective of the current study was to investigate the change in PaO2/FiO2 ratio, the compliance of the respiratory system in VV-ECMO patients with persistent hypoxemia. Measurements were taken before PP, 1 h after the start of the PP, at the end of the PP cycle.

The secondary objective of this study was to assess the safety and feasibility of emergency positioning for patients with severe ARDS during ECMO treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of SARS COV 2 infection complicated by ARDS, and needed a VV ECMO.
patient who presented refractory hypoxemia during VV ECMO.

Exclusion criteria

patient who has received ECMO V-A or ECMO VV for reasons other than ARDS.

Treatment and study plan

Prone position on ECMO patient

Other

blood gas analysis before and after PP

Primary outcomes

amelioration of PaO2/FiO2

Time frame: through study completion, an average of 1 yea

the investigators recoordeed Blood gas analysis before and after Prone position

Sponsors and collaborators

Lead sponsor

Mohammed VI University Hospital

Other

Registry information

Official study title

Prone Position During ECMO in Covid Hypoxaemic Patient :A PROCESS-compliant Case Series From the Eastern Morocco

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: Aug 6, 2021
Registry last updated: Aug 13, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed