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NCT Number: NCT07083973

Prone Position Assessed by 3D EIT

To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.

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Key information

Conditions

ARDS (Acute Respiratory Distress Syndrome) Acute Lung Injury Lung Diseases Lung Injury Respiration Disorders Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100730, China

Location status: Recruiting

Location contact

Yun Long

CONTACT

[email protected]

15201518815

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients on mechanical ventilation.
  • Diagnosis of ARDS was based on the Berlin definition
  • Patients in need of prone position because of clinical condition

Exclusion criteria

  • Under 18 years of age.
  • Pregnant women;
  • Ribcage malformation
  • Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).

Treatment and study plan

Prone position

Behavioral

Patients were ventilated based on the ARDS-Net recommendations . Patients were kept in a supine position. The process of lung ventilation and perfusion assessment was as follows:

  • PEEP was determined by the attending doctor and was kept the same during the supine and prone period.
  • 3D-EIT was used to monitor the ventilation and perfusion of ARDS patients at three timepoints: T1: supine position, T2: prone position at 30min, T3: prone position over 10 hours.

Primary outcomes

  1. Regional ventilation monitored by EIT

    Time frame: 5-10minutes

    Using EIT to monitor the regional ventilation during supine and prone position, to monitor the ventilation distribution change.

  2. Regional perfusion monitored by EIT

    Time frame: 5-10minutes

    Using EIT to monitor the regional perfusion during supine and prone position, to monitor the ventilation distribution change.

  3. V/Q monitored by EIT

    Time frame: 5-10minutes

    Ventilation and perfusion monitored by EIT in supine and prone position. To evaluate the V/Q match, deadspace and shunt lung region.

Secondary outcomes

  1. Respiratory system compliance

    Time frame: 1 day

    Monitor the respiratory system compliance during supine and prone position

  2. SpO2

    Time frame: 1 day

    Monitor the SpO2 during supine and prone position

Study contacts

Contact information is provided by the study sponsor or research team.

Huaiwu He

CONTACT

[email protected]

01069152301

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Prone Position Assessment by 3D EIT in ARDS Patients

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2025
Registry last updated
Jan 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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