Prone Duration in COVID-19 ARDS

The aim of this observational study is to learn the effects of prone position duration on patient outcomes in patients with severe acute respiratory distress syndrome (ARDS) due to Coronavirus Disease - 2019 (COVID-19). The main question it aims to answer is:

Does the length of prone position duration affect gas exchange in patients with severe ARDS and is there a difference between genders in this regard? The differences in gas exchange between those who have been in prone position for 16-24 hours and those who have been in prone position for 24-36 hours as part of severe ARDS treatment will be examined.

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Key information

Conditions

COVID - 19 Acute Respiratory Distress Syndrome (ARDS) Behavior COVID-19 Coitus Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Sexual Behavior Virus Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

İstanbul University - Cerrahpaşa, Cerrahpaşa Medical Faculty

Istanbul, 34153, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

>18 years old
hospitalized for more than 48 hours
patients diagnosed with COVID-19
intubated patients
underwent prone positioning for longer than 16 hours starting from the first session

Exclusion criteria

Pregnant females
Patients under the age of 18
Those who did not reach 16 hours duration of prone position for various reasons (unintentional extubation, ventilation problems, hemodynamic instability, cardiac arrest-prearrest)

Treatment and study plan

Primary outcomes

Calculation of PaO2/FiO2 ratio during short and long prone periods

Time frame: At each prone session, calculation will be started one hour before the pronation and finished one hour after returning supine.

Partial arterial oxygen pressure/Fraction of inspired oxygen (PaO2/FiO2) ratio changes before, during and after pronation at each group will be calculated.

Secondary outcomes

Measurement of PaCO2 during short and long prone periods

Time frame: At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine.

Partial arterial carbon dioxide pressure (PaCO2) changes before, during and after pronation at each group will be measured.
Measurement of PEEP during short and long prone periods

Time frame: At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine.

Positive end-expiratory pressure (PEEP) changes before, during and after pronation at each group will be measured.

Sponsors and collaborators

Lead sponsor

Istanbul University - Cerrahpasa

Other

Registry information

Official study title

Impact of Prone Position Duration and Sex Differences on Ventilation and Oxygenation in COVID-19 ARDS Patients: a Retrospective Cohort Study.

Acronym: PRODUR-CARDS

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Jan 9, 2025
Registry last updated: Jan 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed