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Completed

NCT Number: NCT04947475

Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community

The purpose of this study is to evaluate the efficacy a Screening, Brief Intervention, and Referral to Treatment (SBIRT) program for linking opioid dependent individuals currently incarcerated or in probation in Moldova, Kyrgyzstan, and Ukraine to opioid substitution therapy in the community after release or during their probation period.

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Key information

Conditions

Opioid-use Disorder Actinomycetales Infections Bacterial Infections Bacterial Infections and Mycoses Behavior Behavioral Symptoms Blood-Borne Infections Chemically-Induced Disorders Communicable Diseases DNA Virus Infections Depression Digestive System Diseases Flaviviridae Infections Genital Diseases Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections HIV Infections Hepadnaviridae Infections Hepatitis Hepatitis B Hepatitis C Hepatitis, Viral, Human Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections Liver Diseases Mental Disorders Mycobacterium Infections Narcotic-Related Disorders Opioid-Related Disorders RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Bacterial Sexually Transmitted Diseases, Viral Spirochaetales Infections Substance-Related Disorders Syphilis Treponemal Infections Tuberculosis Urogenital Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

AIDS Foundation East-West, Bishkek, Kyrgyzstan

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years of age or older
  • Within 180 days of release or possible release (eligible for parole) to the community, but greater than 7 days to release to the community OR currently in probation.
  • FOR THOSE IN PRISON: Relocating to a location within 30 km (approximately 60-minute commute) of the referred Narcology center. Each participant will be asked the address he/she is planning to reside under that will be immediately checked on the map to determine the travel time. A participant then will be asked if he/she would be willing to travel the distance to a particular OAT site. If a person does not meet this inclusion criterion, he/she will be referred to a local harm reduction center.
  • Meets ICD-10 screening criteria for pre-incarceration opioid dependence

FOR THOSE IN PROBATION:

  • Living within 30 km of an OAT delivery site
  • Not having received OAT in the last 15 days.
  • Positive for OUD

Exclusion criteria

  • Pregnant or may become pregnant
  • FOR THOSE IN PRISON: Will be released from prison in 7 days or less.

Treatment and study plan

SBIRT

Behavioral

First, the BI is designed to inform potential participants on the risks of substance misuse, abuse, and dependency by illustrating the potential hazards and adverse health consequences. Second, the BI aims to motivate potential participants to reduce risky behavior (e.g., continued drug use) and seek treatment for their substance dependence disorder. In our BI, we will provide evidence-based information on Opioid Agonist Therapy (OAT) that is available to them in the community upon release or in the community. We will inform them of the risks and benefits of OAT and explain to them how OAT can be accessed in the community. OAT is provided at no cost to Ukrainian, Moldovan, and Kyrgyz citizens with opioid dependence. The BI will last approximately 20 minutes and time will be made available for them to ask questions. The BI will not be audio recorded.

Primary outcomes

  1. Enrollment on OAT

    Time frame: 12 months

    Total number of participants who enroll on OAT divided by the number of participants who underwent study procedures, per country.

Secondary outcomes

  1. OAT Knowledge

    Time frame: 6 month

    Overall mean change in composite score of knowledge of OAT pre vs post intervention stratified by study groups (enrolled vs not en rolled on OAT) at the 6-month mark.

  2. OAT Attitudes

    Time frame: 6 months

    Overall mean change in composite score of attitudes towards OAT pre vs post intervention stratified by study groups (enrolled vs not en rolled on OAT) at the 6-month mark.

  3. Interest in OAT

    Time frame: 6 months

    Overall mean change in composite score of interest in initiating OAT pre vs post intervention stratified by study groups (enrolled vs not en rolled on OAT) at the 6-month mark.

  4. OAT Difficulty

    Time frame: 6 months

    Overall mean change in composite score of difficulty in initiating OAT pre vs post intervention stratified by study groups (enrolled vs not en rolled on OAT) at the 6-month mark.

  5. OAT Importance

    Time frame: 6 months

    Overall mean change in composite score of importance of initiating OAT pre vs post intervention stratified by study groups (enrolled vs not en rolled on OAT) at the 6-month mark.

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • AFEW Kyrgyzstan
  • AFI - Act For Involvement
  • National Institute on Drug Abuse (NIDA)
  • Ukrainian Institute on Public Health Policy

Registry information

Acronym: MATLINK

Important dates

Study start
2017
Primary completion
2023
Study completion
2023
First posted
Jul 1, 2021
Registry last updated
May 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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