Skip to main content
OpenTrials
Enrolling by Invitation

NCT Number: NCT06883838

Project CASCADE: Community and Academic Synergy for Cancer Survivorship Care Delivery Enhancement

The purpose of this study is to implement a clinic-level cancer survivorship care delivery intervention in partnership with community health center clinicians, patients, and community representatives to test effectiveness of the intervention to improve patient and clinician outcomes and to evaluate implementation of the intervention using an iterative, concurrent mixed-methods approach guided by the Practice Change Model.

Enrolling by Invitation

Interested in participating?

Request Info

Key information

Conditions

Cancer Survivorship

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Texas Health Science Center, Houston

Houston, Texas, 77030, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(participants):

-at least one visit to the Community Health Centers (CHCs) in the prior year

Exclusion criteria

(participants):

  • no history of cancer recorded in the problem list or past medical history in the medical record

Inclusion criteria

(clinicians):

-employed clinicians (e.g. physicians, nurses, pharmacists, or other allied health professionals) and non-clinician staff of the participating CHC clinics

Treatment and study plan

Survivorship care delivery intervention

Behavioral

Guided by the Practical, Robust Implementation and Sustainability Model (PRISM), the intervention includes three evidence-based components:

  • Training: This will include provider-to-provider tele-mentoring using Enhancing Community Health Outcomes (ECHO).
  • Tracking: This includes systematically assessing cancer history and monitoring survivors' care to plan and organize subsequent care.
  • Coordinating care for cancer survivors. Each clinic leader will designate a staff member (or members) as the care coordinator champion after exploring current clinic staff, skills, and capacity of various staff roles.

Primary outcomes

  1. Proportion of eligible cancer survivors screened for second primary cancers

    Time frame: every 6 months from baseline to end of study (about 36 months from baseline)

    Data derived from electronic health records

Secondary outcomes

  1. Change in proportion of primary care clinician knowledge of cancer survivorship care

    Time frame: baseline, six months following end of intervention period

    Assessed by self-administered survey

  2. Change proportion of survivors that report better experience of provider communication as assessed by the adapted Consumer Assessment of Healthcare Providers and Systems (CAHPS 4.0)

    Time frame: baseline, six months following end of intervention period

  3. Change proportion of survivors that report better experience of care coordination as assessed by the adapted Consumer Assessment of Healthcare Providers and Systems (CAHPS 4.0)

    Time frame: baseline, six months following end of intervention period

  4. Proportion of survivors who received guideline-recommended surveillance for the most prevalent cancers (breast colorectal, prostate, cervical, and lung)

    Time frame: every 6 months from baseline to end of study (about 36 months from baseline)

    Per national guidelines [National Comprehensive Cancer Network (NCCN), U.S. Preventive Services Task Force (USPSTF)]; data derived from electronic health records

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Enhancing Primary Care Capacity for Cancer Survivorship Care Delivery in Community Health Clinics

Acronym: CASCADE

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Mar 19, 2025
Registry last updated
Jul 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.