Project 4: ACHIEVE PATHFINDER

Project 4 of ACHIEVE GREATER aims to improve outcomes for symptomatic (Stage C) HF. This is vitally important because HF is the most common final manifestation of cardiometabolic diseases in the U.S., accounting for nearly 400,000 deaths and 900,000 hospitalizations per year. Growing evidence implicates air pollutants adversely impact HF and its prognosis. For example, among 12,474 HF patients in North Carolina, hospital readmission rates at 90-days were increased by 13-14% for every 1 μg/m3 elevation in fine particulate matter <2.5 µm air pollution (PM2.5) levels. While average U.S. air quality has improved, urban communities continue to have higher levels of exposure. Indeed, Detroit residents face the highest PM2.5 concentrations in Michigan (97th percentile for the U.S.). We hypothesize that this may contribute to worse outcomes among HF patients in Detroit, including an unacceptably high rate of death or rehospitalization (22% based on Henry Ford Health [HFH] data for 2022) at 90-days post-discharge. To combat this problem, we propose to test an emerging therapeutic intervention, the portable air cleaner (PAC), that we hypothesize will reduce personal-level exposure to PM2.5 resulting in improved clinical outcomes for HF patients. This novel intervention is both practical and scalable, and thus has the potential to revolutionize the treatment of HF and improve related outcomes nationwide.

Inclusion criteria

• Currently in the emergency room or hospitalized with plan to be discharged to home, or
• Diagnosis of heart failure
• BNP>200 ng/L or NTproBNP>1000 ng/L during hospitalization or within 1 month prior to screening
• Expected ability to fully participate in study (can tolerate study processes, no long travel)

Exclusion criteria

• Hemodialysis dependent
• If dialysis is being considered by participant's care team and their eGFR value is <30 mL/min/1.73 sq m
• Life expectancy of less than one year
• Inability to provide written informed consent
• Age less than 18 years old
• Patients with a left ventricular assist device (LVAD)
• Heart transplant recipients
• Individuals who regularly use a HEPA air cleaner in their home at screening
• Current smokers of nicotine or marijuana
• Severe aortic or mitral valve disease
• Has a scheduled, non-diagnostic cardiac procedure within 30 days prior, or in the next 90 days from screening (e.g. PCI, resynchronization, any cardiac surgery)
• If the PI decides for any reason that participation in the trial is not in the best interest of the patient