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Completed

NCT Number: NCT00605124

Progressive Exercise After Total Knee Arthroplasty (TKA)

Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.

The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.

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Key information

Conditions

Osteoarthritis Arthritis Behavior Joint Diseases Motor Activity Musculoskeletal Diseases Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ceneral Finland Health Care District

Jyväskylä, FIN-40620, Finland

About this study

Many studies have shown, that after TKA pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. To find out the effects of progressive exercise program the investigators will perform, 6 weeks after TKA, a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • primary unilateral TKA for knee osteoarthritis

Exclusion criteria

  • Rheumatoid arthritis
  • Fibromyalgia
  • Bilateral TKA
  • Heart or lung disease, which prevent training
  • Unstable serious disease (cancer)
  • Reduced cooperation (drug, alcohol abuse, mental illness)

Treatment and study plan

Knee muscle exercises

Other

Home exercises three times a week, control every three months

Primary outcomes

  1. Functional tests, pain

    Time frame: baseline , 6 weeks after operation (start of training), after 12 months training

    Timed-Up and Go-test, Visual analogue scale (VAS)

Secondary outcomes

  1. Knee muscle strength

    Time frame: baseline, 6 weeks after operation (start of training), after 12 months training

    isometric strength of quadriceps and hamstrings

  2. Health related quality of life

    Time frame: baseline and 12 months

    SF-36

  3. gait analysis

    Time frame: baseline, 6 weeks postoperatively, 12 months

Sponsors and collaborators

Lead sponsor

Jyväskylä Central Hospital

Other

Registry information

Official study title

Progressive Exercise After Total Knee Arthroplasty: A Randomised Controlled Trial

Important dates

Study start
2008
Primary completion
2010
Study completion
2012
First posted
Jan 30, 2008
Registry last updated
Mar 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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