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NCT Number: NCT07236671

Progression Patterns of Choroidal Venous Alterations

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

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Key information

Conditions

Pachychoroid Disease

Age range

45 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hong Kong University, Hong Kong

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About this study

This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 45 years or older.
  • Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
  • Willing to undergo pupil dilation, and protocol-required procedures for both eyes
  • Willing to provide written informed consent

Exclusion criteria

  • Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
  • Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
  • Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
  • Pregnant or nursing women
  • Persons who are unable to give informed consent

Treatment and study plan

Primary outcomes

  1. Progression of choroidal venous alterations

    Time frame: 3 years

    Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.

Secondary outcomes

  1. Incidence of progression of pachychoroid disease manifestation

    Time frame: 3 years

    New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.

  2. Risk factors associated with progression of choroidal venous alteration

    Time frame: 3 years

    Assessment of demographic, cilinical, and imaging parameters associated with progression.

Study contacts

Contact information is provided by the study sponsor or research team.

Gemmy Cheung

CONTACT

[email protected]

+65 63227460

Sponsors and collaborators

Lead sponsor

Singapore National Eye Centre

Other Gov

Collaborators

  • Hong Kong University
  • National University Hospital, Singapore
  • University of Malaya

Registry information

Official study title

International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations

Acronym: CVA

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Nov 19, 2025
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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