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OpenTrials
Completed

NCT Number: NCT01668888

Progranulin and CTRP3 in Metabolic Syndrome

Inflammation has been known to be a pivotal pathogenic mechanism of obesity-related disorders such as type 2 diabetes, metabolic syndrome and atherosclerosis. Adipose tissue functions as a major endocrine organ by adipokine mediated modulation of a number of signaling cascades in target tissues, that has pro-inflammatory or anti-inflammatory activities. Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to clarify the clinical meaning of these two adipokines in the subjects with or without metabolic syndrome

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Key information

Conditions

Metabolic Syndrome Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Korea University Guro Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20<age<80
  • apparently healthy subjects

Exclusion criteria

  • a history of CVD
  • diabetes
  • stage 2 hypertension
  • malignancy
  • severe renal or hepatic disease

Treatment and study plan

Primary outcomes

  1. Serum concentration of progranulin in the subjects with metabolic syndrome

    Time frame: 12week

  2. Serum concentration of CTRP3 in the subjects with metabolic syndrome

    Time frame: 12week

Secondary outcomes

  1. The relationship of serum progranulin levels with cardiovascular risk factors

    Time frame: 12 week

  2. The relationship of serum CTRP3 levels with cardiovascular risk factors

    Time frame: 12 week

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Aug 20, 2012
Registry last updated
Aug 20, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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