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OpenTrials
Completed

NCT Number: NCT01419353

Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol

The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

Up to 38 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Meir Medical Center

Kfar Saba, Israel

About this study

A randomised controlled trial in which study group will be given estrogen derivative before ovarian stimulation in GnRH antagonist protocol and compared to the classical GnRH agonist protocol.Estrogen will be given P.O , "PROGYNOVA' , in a dose of 2 mg /d, starting day 2 of menses and until first Monday to follow. Main outcome measure will be ability to control the ovum pickup day, calculated as a rate of ideal pickups divided by the entire pickup number. All women enrolled will be under 38 years of age, with a clear indication for IVF other than ovulatory dysfunction. women with past 4 treatment failures will be excluded as well as cases in which sperm achieved in surgical methods.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IVF treatment in the following indications: Male, Mechanical, Unexplained
  • Age<38 years
  • Treatment Cycle number 1-4

Exclusion criteria

  • Ovulatory disorder as an indication for IVF
  • Repeated failure in previous IVF treatments (> than 4 cycles)
  • Sperm used for treatment was retrieved by surgical procedure

Treatment and study plan

estradiol valerate

Drug

2 mg P.O / day for 1-6 days.

Primary outcomes

  1. ovum pickup rate that took place between Sunday to Thursday without a compromise

    Time frame: a year

    number of Pickups that took place between Sunday to Thursday (without a compromise in treatment) \\ by the entire pickup number

Secondary outcomes

  1. pregnancy rate

    Time frame: a year

    comparison of pregnancy rate between the 2 groups. calculated per cycle

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Aug 18, 2011
Registry last updated
Dec 24, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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