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Active, Not Recruiting

NCT Number: NCT05653765

Prognostic Value of the AMR Measured After PPCI in STEMI Patients

The goal of this observational study is to learn about in STEMI with Primary PCI Patients. The main questions it aims to answer are:

* To determine the value of AMR in predicting the long-term clinical prognosis of patients with STEMI after PPCI, and to find the best cut-off value. * Analyze the factors of PPCI affecting AMR and explore the effective measures of PPCI microcirculation protection.

Radiographic images of STEMI receiving primary PCI treatment in several chest pain centers in China will be included. The last image of the infarct-related vessel will be used as a target to calculate its AMR. The relationship between AMR and long-term clinical prognosis was analyzed.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Coronary Heart Disease Cardiovascular Diseases Coronary Disease Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Shangqiu first people's Hospital, Shangqiu, Henan, China

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 or older
  • Type 1 myocardial infarction
  • Receive PPCI

Exclusion criteria

  • Failed to identify culprit vessels.
  • Structural heart disease with moderate to severe aortic valve or mitral regurgitation and or stenosis that may affect cardiac function
  • Dialysis patients with severe renal insufficiency
  • Severe and uncontrollable arrhythmia
  • Complicated with dilated cardiomyopathy
  • Unable to tolerate dual antiplatelet therapy
  • Severe and uncontrollable anemia
  • Hyperthyroidism
  • TIMI blood flow 0-1 grade after PPCI

Treatment and study plan

Primary outcomes

  1. MACEs

    Time frame: 12 months

    cardiac death, hospitalization for heart failure, target vessel revascularization，non-fatal MI

Secondary outcomes

  1. cardiac death

    Time frame: 12 months

    All cause deaths will be considered cardiac unless a definite noncardiac cause can be established.

  2. hospitalization for heart failure

    Time frame: 12 months

    Hospitalization for heart failure was defined as admission because of new or deteriorating signs and symptoms of heart failure combined with the findings of noninvasive imaging or elevated B-type natriuretic peptide(BNP) and/or N-terminal pro-BNP concentration, and a discharge diagnosis of congestive heart failure.

  3. target lesion revascularization

    Time frame: 12 months

    The following 3 conditions need to be met at the same time:

    • The new stenosis that developed within previously treated coronary segments and within 5 mm of their borders;
    • The new stenosis resulted in the vessel μQFR ≤ 0.80;
    • The patient subsequently underwent repeat PCI or coronary artery bypass grafting (CABG).

  4. Repeated myocardial infarction

    Time frame: 12 months

    Repeated myocardial infarction

Sponsors and collaborators

Lead sponsor

Henan Institute of Cardiovascular Epidemiology

Other

Registry information

Official study title

Prognostic Value of the Angio-based Microvascular Resistance Use One Single Angiographic View Measured After Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction Patients

Acronym: EARLYMYOAMR

Important dates

Study start
2022
Primary completion
2023
Study completion
2025
First posted
Dec 16, 2022
Registry last updated
Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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