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Completed

NCT Number: NCT03934892

Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries

Tissue hypoperfusion during cardiopulmonary bypass (CPB) affects cardiac surgical outcomes. Lactate, an end product of anaerobic glycolysis from oxygen deficit, is an obtainable marker of tissue hypoxia. The investigators aimed to determine the value of blood lactate level during CPB in adult cardiac surgeries in predicting outcomes.

The investigators retrospectively reviewed the patients underwent cardiac surgeries with CPB from January 2015 to December 2015. The patient's characteristics, pre-operative status, surgical type, and intra-operative lactate levels were collected. The outcomes were in-hospital mortality and complications. Receiver operating characteristics (ROC) curves were used to assess the ability of peak lactate level during CPB to predict in-hospital mortality.

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Key information

Conditions

Cardiopulmonary Bypass Lactate

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

About this study

The baseline characteristics, including age, gender, body mass index (BMI), comorbidities, left ventricular ejection fraction (LVEF, %), European system for cardiac operative risk evaluation II (EuroSCORE II), pre-operative hematocrit, and serum creatinine levels were recorded. The surgical type was classified as coronary artery bypass grafting (CABG), valve surgery, combined surgery including CABG and valve surgery, great vessel surgery including aortic dissection, and other surgeries. The priority of surgery was classified as elective, urgent, and emergent. The intra-operative variables included CPB time, aortic cross-clamp time, initial lactate level at the beginning of the operation, and the peak lactate level during CPB.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults patients underwent cardiac surgeries with cardiopulmonary bypass from January 2015 to December 2015

Exclusion criteria

  • patients with missing data from records

Treatment and study plan

serum lactate

Diagnostic Test

check lactate levels during cardiopulmonary bypass in adult cardiac operations

Primary outcomes

  1. in-hospital mortality

    Time frame: From date of inclusion until date of death from any cause during hospitalization, assessed up to one year

    peak lactate level during cardiopulmonary bypass predicts in-hospital mortality

Sponsors and collaborators

Lead sponsor

Hualien Tzu Chi General Hospital

Other

Registry information

Official study title

Prognostic Value of Peak Lactate During Cardiopulmonary Bypass in Adult Cardiac Surgeries: a Cohort Study

Important dates

Study start
2015
Primary completion
2018
Study completion
2018
First posted
May 2, 2019
Registry last updated
May 2, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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