Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

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Key information

Conditions

Cardiac Surgery Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications

Age range

75 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen

Ludwigshafen, 67063, Germany

About this study

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion criteria

positive cardiac troponin T test within the week before surgery
patients undergoing emergent procedures
patients with preoperative mechanical cardiac support
patients undergoing hemodialysis

Sponsors and collaborators

Lead sponsor

Klinikum Ludwigshafen

Other

Registry information

Official study title

Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Important dates

Study start: 2007
Study completion: 2007
First posted: Dec 27, 2006
Registry last updated: Jan 30, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed