Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT05613673

Prognostic Value of Different Nutritional Screening Tools in Acute Pancreatitis

The goal of this observational study is to compare the prognostic value of different nutritional screening tools to predict the course of acute pancreatitis.

The main questions it aims to answer are:

* Which nutritional screening tool performs best to predict length of hospital stay? * Which nutritional screening tool performs best to predict clinical outcome (disease severity, length of hospital stay, mortality, need for rehospitalization)?

Participants will answer questions regarding their nutritional status and undergo basic anthropometric assessments (e.g. measurement of waist circumference) to evaluate their risk of malnutrition.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Acute Pancreatitis Digestive System Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Pancreatic Diseases Pancreatitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Medicine Greifswald

Greifswald, 17475, Germany

About this study

Malnutrition seems to be related to an adverse outcome of acute pancreatitis. However, it is still unclear which of the various available nutritional screening tools is suited best to predict the clinical outcome in hospitalized patients with acute pancreatitis.

Therefore, in this study we compare the predictive performance of 6 different nutritional screening tools that are commonly applied in clinical practice regarding their respective associations with severity of acute pancreatitis, length of hospital stay, mortality and need for rehospitalization.

To determine patients' nutritional status, subjects will be inquired about their recent food intake as well as body weight and undergo basic anthropometric assessments according to the different screening tools.

Six months after the initial diagnosis patients will be contacted via mail to report on need for rehospitalization due to acute pancreatitis during this time period.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • verified diagnosis of acute pancreatitis
  • provision of informed consent

Exclusion criteria

  • pregnancy
  • inability to provide consent

Treatment and study plan

No intervention - observational study only

Other

No intervention - observational study only

Primary outcomes

  1. Relation of Nutritional Risk Screening 2002 to length of hospital stay

    Time frame: Baseline

    Association between Nutritional Risk Screening 2002 (NRS-2002) result and length of hospital stay. NRS-2002 score ranges from 0 to 7, with higher values indicating greater nutritional risk.

Secondary outcomes

  1. Relation of Nutritional Risk Index to length of hospital stay

    Time frame: Baseline

    Association between Nutritional Risk Index (NRI) result and length of hospital stay. NRI is a continuous measure, with lower values indicating greater nutritional risk.

  2. Relation of Mini Nutritional Assessment - Short Form to length of hospital stay

    Time frame: Baseline

    Association between Mini Nutritional Assessment - Short Form (MNA-SF) result and length of hospital stay. MNA-SF score ranges from 0 to 14, with lower values indicating greater nutritional risk.

  3. Relation of Subjective Global Assessment to length of hospital stay

    Time frame: Baseline

    Association between Subjective Global Assessment result and length of hospital stay. SGA scores of A, B, and C indicate no malnutrition, moderate malnutrition or severe malnutrition, respectively.

  4. Relation of Malnutrition Universal Screening Tool to length of hospital stay

    Time frame: Baseline

    Association between Malnutrition Universal Screening Tool (MUST) result and length of hospital stay. MUST score ranges from 0 to 6, with higher values indicating greater nutritional risk.

  5. Relation of Short Nutritional Assessment Questionaire to length of hospital stay

    Time frame: Baseline

    Association between Short Nutritional Assessment Questionaire (SNAQ) result and length of hospital stay. SNAQ score ranges from 0 to 7, with higher values indicating greater nutritional risk.

  6. Relation of fat-free mass to length of hospital stay

    Time frame: Baseline

    Association between fat-free mass determined by bioelectrical impedance analysis and length of hospital stay.

  7. Relation of fat mass to length of hospital stay

    Time frame: Baseline

    Association between fat mass determined by bioelectrical impedance analysis and length of hospital stay.

  8. Relation of skeletal muscle mass to length of hospital stay

    Time frame: Baseline

    Association between skeletal muscle mass determined by computed tomography and length of hospital stay.

  9. Relation of waist circumference to length of hospital stay

    Time frame: Baseline

    Association between waist circumference and length of hospital stay.

  10. Relation of albumin to length of hospital stay

    Time frame: Baseline

    Association between plasma albumin concentration at admission and length of hospital stay.

  11. Relation of C-reactive protein to length of hospital stay

    Time frame: Baseline

    Association between plasma C-reactive protein concentration at admission and length of hospital stay.

  12. Relation of Nutritional Risk Screening 2002 to disease severity

    Time frame: Baseline

    Association between Nutritional Risk Screening 2002 (NRS-2002) result and severity of acute pancreatitis based on the Revised Atlanta Classification. NRS-2002 score ranges from 0 to 7, with higher values indicating greater nutritional risk. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  13. Relation of Nutritional Risk Index to disease severity

    Time frame: Baseline

    Association between Nutritional Risk Index (NRI) result and severity of acute pancreatitis based on the Revised Atlanta Classification. NRI is a continuous measure, with lower values indicating greater nutritional risk. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  14. Relation of Mini Nutritional Assessment - Short Form to disease severity

    Time frame: Baseline

    Association between Mini Nutritional Assessment - Short Form (MNA-SF) result and severity of acute pancreatitis based on the Revised Atlanta Classification. MNA-SF score ranges from 0 to 14, with lower values indicating greater nutritional risk. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  15. Relation of Subjective Global Assessment to disease severity

    Time frame: Baseline

    Association between Subjective Global Assessment (SGA) result and severity of acute pancreatitis based on the Revised Atlanta Classification. SGA scores of A, B, and C indicate no malnutrition, moderate malnutrition or severe malnutrition, respectively. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  16. Relation of Malnutrition Universal Screening Tool to disease severity

    Time frame: Baseline

    Association between Malnutrition Universal Screening Tool (MUST) result and severity of acute pancreatitis based on the Revised Atlanta Classification. MUST score ranges from 0 to 6, with higher values indicating greater nutritional risk. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  17. Relation of Short Nutritional Assessment Questionaire to disease severity

    Time frame: Baseline

    Association between Short Nutritional Assessment Questionaire (SNAQ) result and severity of acute pancreatitis based on the Revised Atlanta Classification. SNAQ score ranges from 0 to 7, with higher values indicating greater nutritional risk. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  18. Relation of fat-free mass to disease severity

    Time frame: Baseline

    Association between fat-free mass determined by bioelectrical impedance analysis and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  19. Relation of fat mass to disease severity

    Time frame: Baseline

    Association between fat mass determined by bioelectrical impedance analysis and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  20. Relation of skeletal muscle mass to disease severity

    Time frame: Baseline

    Association between skeletal muscle mass determined by computed tomography and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  21. Relation of waist circumference to disease severity

    Time frame: Baseline

    Association between waist circumference and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  22. Relation of albumin to disease severity

    Time frame: Baseline

    Association between plasma albumin concentration at admission and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  23. Relation of C-reactive protein to disease severity

    Time frame: Baseline

    Association between plasma C-reactive protein concentration at admission and severity of acute pancreatitis based on the Revised Atlanta Classification. Based on the Revised Atlanta Classification acute pancreatitis can be graded as mild, moderate, or severe.

  24. Relation of Nutritional Risk Screening 2002 to mortality

    Time frame: Baseline

    Association between Nutritional Risk Screening 2002 (NRS-2002) result and in-hospital mortality. NRS-2002 score ranges from 0 to 7, with higher values indicating greater nutritional risk.

  25. Relation of Nutritional Risk Index to mortality

    Time frame: Baseline

    Association between Nutritional Risk Index (Index) result and in-hospital mortality. NRI is a continuous measure, with lower values indicating greater nutritional risk.

  26. Relation of Mini Nutritional Assessment - Short Form to mortality

    Time frame: Baseline

    Association between Mini Nutritional Assessment - Short Form (MNA-SF) result and in-hospital mortality. MNA-SF score ranges from 0 to 14, with lower values indicating greater nutritional risk.

  27. Relation of Subjective Global Assessment to mortality

    Time frame: Baseline

    Association between Subjective Global Assessment (SGA) result and in-hospital mortality. SGA scores of A, B, and C indicate no malnutrition, moderate malnutrition or severe malnutrition, respectively.

  28. Relation of Malnutrition Universal Screening Tool to mortality

    Time frame: Baseline

    Association between Malnutrition Universal Screening Tool (MUST) result and in-hospital mortality. MUST score ranges from 0 to 6, with higher values indicating greater nutritional risk.

  29. Relation of Short Nutritional Assessment Questionaire to mortality

    Time frame: Baseline

    Association between Short Nutritional Assessment Questionaire (SNAQ) result and in-hospital mortality. SNAQ score ranges from 0 to 7, with higher values indicating greater nutritional risk.

  30. Relation of fat-free mass to mortality

    Time frame: Baseline

    Association between fat-free mass determined by bioelectrical impedance analysis and in-hospital mortality.

  31. Relation of fat mass to mortality

    Time frame: Baseline

    Association between fat mass determined by bioelectrical impedance analysis and in-hospital mortality.

  32. Relation of skeletal muscle mass to mortality

    Time frame: Baseline

    Association between skeletal muscle mass determined by computed tomography and in-hospital mortality.

  33. Relation of waist circumference to mortality

    Time frame: Baseline

    Association between waist circumference and in-hospital mortality.

  34. Relation of albumin to mortality

    Time frame: Baseline

    Association between plasma albumin concentration at admission and in-hospital mortality.

  35. Relation of C-reactive protein to mortality

    Time frame: Baseline

    Association between plasma C-reactive protein concentration at admission and in-hospital mortality.

  36. Relation of Nutritional Risk Screening 2002 to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Nutritional Risk Screening 2002 (NRS-2002) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. NRS-2002 score ranges from 0 to 7, with higher values indicating greater nutritional risk.

  37. Relation of Nutritional Risk Index to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Nutritional Risk Index (NRI) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. NRI is a continuous measure, with lower values indicating greater nutritional risk.

  38. Relation of Mini Nutritional Assessment - Short Form to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Mini Nutritional Assessment - Short Form (MNA-SF) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. MNA-SF score ranges from 0 to 14, with lower values indicating greater nutritional risk.

  39. Relation of Subjective Global Assessment to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Subjective Global Assessment (SGA) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. SGA scores of A, B, and C indicate no malnutrition, moderate malnutrition or severe malnutrition, respectively.

  40. Relation of Malnutrition Universal Screening Tool to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Malnutrition Universal Screening Tool (MUST) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. MUST score ranges from 0 to 6, with higher values indicating greater nutritional risk.

  41. Relation of Short Nutritional Assessment Questionaire to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between Short Nutritional Assessment Questionaire (SNAQ) result and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital. SNAQ score ranges from 0 to 7, with higher values indicating greater nutritional risk.

  42. Relation of fat-free mass to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between fat-free mass determined by bioelectrical impedance analysis and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

  43. Relation of fat mass to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between fat mass determined by bioelectrical impedance analysis and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

  44. Relation of skeletal muscle mass to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between skeletal muscle mass determined by computed tomography and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

  45. Relation of waist circumference to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between waist circumference and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

  46. Relation of albumin to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between plasma albumin concentration at admission and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

  47. Relation of C-reactive protein to rehospitalization

    Time frame: 6 months after initial hospital admission

    Association between plasma C-reactive protein concentration at admission and number of rehospitalizations due to acute pancreatitis within 6 months after initial admission to hospital.

Sponsors and collaborators

Lead sponsor

University Medicine Greifswald

Other

Registry information

Official study title

Comparison of the Prognostic Value of Different Nutritional Assessment Scores Regarding the Course in Acute Pancreatitis - a Prospective Trial

Acronym: NuRiPa

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Nov 14, 2022
Registry last updated
Dec 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.