Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma Patients

Nowadays, the tools available to assess the severity of a polytrauma patient in the pre-hospital setting (vital parameters, shock index, MGAP score, Vittel criteria) have their limitations and are sometimes subjective. To date, there are no objective, practical and reproducible tools for triaging these patients. Venous lactataemia also appears to be predictive of poor outcome in severe trauma. However, there are no studies in the literature on capillary lactataemia, which would indicate the potential severity of a polytrauma patient in the pre-hospital setting. However, it is an easily performed, risk-free assay, the results of which can be obtained rapidly at the scene of the accident. The aim of this project is to confirm that, like venous lactataemia, capillary lactataemia can be useful in the pre-hospital phase for predicting a patient's poor outcome. Incorporating this assay into the assessment of potentially severe polytrauma patients in the pre-hospital phase could improve the predictive value of clinical and contextual data and thus enable better referral and management of these patients.

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Key information

Conditions

Polytrauma Multiple Trauma Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Antibes Hospital, Antibes, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient over 18 years of age
Presenting a potentially serious pre-hospital trauma defined by:

o A road accident or a fall of more than 2 metres

Requiring the dispatch of a SMUR 06 team (mobile emergency and resuscitation service)
And transferred to an emergency facility in the Alpes Maritimes with medical assistance.
Consent signed (by the patient or a relative) after the event if it is not possible to sign immediately.
Pregnant women may also take part in the study without any risk to themselves or their child.

Exclusion criteria

Patients with isolated peripheral limb trauma (wrist, elbow, knee, ankle, shoulder)
Patients under legal protection (guardianship, curatorship)
Patients in cardiorespiratory arrest when taken into care by the SMUR (emergency medical services)

Treatment and study plan

capillary blood sampling

Biological

capillary blood sampling during the hospital transfert

Primary outcomes

lactemie value H0

Time frame: at inclusion

dosage of capillary lactemia in mmol/L
lactemie value H6

Time frame: 6 hours

dosage of capillary lactemia in mmol/L

Study contacts

Contact information is provided by the study sponsor or research team.

Marta FERNANDES FEIRRERA, PH

CONTACT

[email protected]

0629847289

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma in Pre-hospital Care

Acronym: CLAT

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: May 13, 2025
Registry last updated: Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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