Prognostic Value Cardiac Dysfunction Assessed by Bedside Echocardiography in Critically Ill COPD Patients Requiring Mechanical Ventilation

Chronic obstructive lung disease (COPD) is a major cause of morbidity and mortality, and is a major reason for ICU admission. Cardiac function is often impaired in this disease but its association with clinical outcome has not been fully established. The study aims to investigate the association between cardiac dysfunction and clinclial outcomes.

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Key information

Conditions

COPD Patients Mechanical Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Jinhua municipal central hospital

Jinhua, Zhejiang, 321000, China

About this study

This is a prospective observational study conducted in a 47-bed mixed ICU of tertiary academic teaching hospital. The study will be performed between January 2014 to December 2015. All patients meeting the diagnostic criteria of AECOPD and admitted to ICU are potentially eligible for the present study. Relevant demographics and laboratory measurements are obtained. Transthoracic echocardiography (TTE) is performed immediately after ICU admission by experienced intensivists. Cox proportional hazard regression model is fitted by using stepwise forward selection and backward elimination technique. If linear assumption is not satisfied, the linear spline function will be used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

COPD patients experiencing episode of exacerbation and require mechanical ventilation were admitted to ICU

Exclusion criteria

COPD patients admitted to ICU due to other reasons (major surgery, ischemic heart disease, and renal failure)
moribund and expected to die within 48 hours
with Do-Not-Resuscitation order

Treatment and study plan

echocardiography examination

Device

patients underwent echocardiography examination

Primary outcomes

28-day mortality

Time frame: 28 days after ICU admission

28 days after ICU admission; if a patient leave ICU before 28-days, it is considered as censored.

Secondary outcomes

duration of mechanical ventilation

Time frame: from ICU admission to extubation, an expected average of 8 days

Sponsors and collaborators

Lead sponsor

Jinhua Central Hospital

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Mar 28, 2014
Registry last updated: Sep 1, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed