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Completed

NCT Number: NCT04763239

Prognostic Significance of Red Blood Cell

Red blood cell (RBC) distribution width (RDW), calculated by dividing the standard deviation of RBC volume by the mean corpuscular volume and multiplied by 100, is routinely reported as part of the complete blood count (CBC) using automated flow cytometry. RDW has been traditionally used as additional information in the differential diagnosis of the cause of anemia.

RDW has been recently reported as a strong prognostic factor in several diseases of various organ systems, including the cardiovascular, respiratory, renal, neurologic, and gastrointestinal systems.It also showed significant associations with ventilator-free days, postoperative outcome, intensive care unit (ICU) discharge outcome, out-of-hospital outcome, and all-cause mortality in critically ill patients. However, most studies were conducted in adult patients. Only a few studies have investigated RDW in children, especially in the critically ill pediatric population.

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Key information

Conditions

Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

1 month–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag faculty of medicine

Sohag, Egypt

About this study

The aim of this study is to know the prognostic significance of red blood cell distribution width ( RDW ) in critically ill pediatric patients as regard ; the duration of hospital & PICU admission ,the use of inotropic drugs and or mechanical ventilation (MV) and the outcome of the case .

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All critically ill pediatric patients, 1 month to 12 years age, admitted to Pediatric intermediate & Intensive Care Unit ( PICU ) in Sohag University Hospital.

Exclusion criteria

  • - patients who received blood transfusion prior to admission in PICU
  • patients with incomplete data for pediatric risk of mortality (PRISM), pediatric sequential organ failure assessment (pSOFA), pediatric logistic organ dysfunction-2 (PELOD-2), and pediatric multiple organ dysfunction syndrome (pMODS) scores were excluded.

Treatment and study plan

Primary outcomes

  1. duration of hospital admission

    Time frame: 6 months

    in days

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Prognostic Significance of Red Blood Cell Distribution Width (RDW) in Critically Ill Pediatric Patients at Sohag University Hospital

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 21, 2021
Registry last updated
Aug 29, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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