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NCT Number: NCT05667259

Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival

This study was conducted to compare the significance of lymph node ratio and absolute count of positive lymph node count on overall survival in patients with rectal cancer who underwent resection with curative intent

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Key information

Conditions

Cancer, Rectum Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases Rectal Neoplasms

Age range

19 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Qena Faculty of Medicine, South Valley University Hospitals

Qina, Egypt

About this study

Retrospective cohort study carried on 229 patients with non-metastatic rectal cancer, admitted in tertiary hospitals along 10 years, between 2012 to 2022, and underwent radical resection surgery with curative intent.

Exclusion criteria

included patients with familial adenomatous polyposis, multiple synchronous or metachronous rectal cancers, early post-operative recurrence or death within 3 months. Demographic, histopathological, follow up and outcome data were collected.

Demographics included age, gender, family history, and chief complaint at presentation. Histopathological data included tumor site, grade, vascular-perineural invasion, total number of lymph nodes removed, and positive lymph nodes.

Lymph node ratio was defined as the ratio of positive lymph nodes to the total number of retrieved lymph nodes in histopathology specimen. Survival was calculated for each patient based on time of surgery to time of death

Statistical analysis will be used to evaluate the effect of lymph node ratio on overall survival.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with rectal cancer of stage I-III.
  • patients underwent radical resection with curative intent.

Exclusion criteria

  • Patients with Familial Adenomatous Polyposis, multiple synchronous or metachronous rectal cancers.
  • Early post-operative recurrence, or death within 3 months.

Treatment and study plan

Surgical resection for cancer rectum

Other

Curative resection for cancer recum

Primary outcomes

  1. Overall Survival

    Time frame: up to 10 years (From date of surgery to the date date of death)

    Survival was calculated for each patient based on time of surgery to time of death.

Sponsors and collaborators

Lead sponsor

South Valley University

Other

Registry information

Official study title

Prognostic Significance of Lymph Node Ratio in Rectal Cancer on Overall Survival: An Alternative Not a Substitute

Important dates

Study start
2012
Primary completion
2022
Study completion
2022
First posted
Dec 28, 2022
Registry last updated
Dec 28, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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