Prognostic Prediction Model of Patients With AcUte Stroke undeRgoing EndOvascular TheRApy (AURORA)

Inclusion criteria

• Age ≥18 years;
• NIHSS score ≥4;
• Image-confirmed (CTA/MRA/DSA) intracranial large artery occlusion;
• ASPECT (anterior circulation) or PC-ASPECT (posterior circulation) score ≥3;
• Endovascular treatment including arterial thrombolysis, mechanical thrombolysis, and angioplasty (onset to puncture time is recommended to be less than 8 hours for anterior circulation and less than 12 hours for posterior circulation; those exceeding the time window will be determined by the neurointerventionalist through imaging assessment);
• Signed informed consent by the patient or legal representative

Exclusion criteria

• Pre-stroke mRS score >2;
• Intracranial bleeding disorders: cerebral hemorrhage, subarachnoid hemorrhage, etc.;
• presence of coagulation disorders, history of systemic bleeding, history of thrombocytopenia or neutropenia;
• Renal insufficiency with elevated blood creatinine (greater than 2 times the upper limit of normal);
• Presence of severe cardiopulmonary disease that, in the opinion of the investigator, makes participation in this study unsuitable; patients with a life expectancy of less than 3 months or otherwise unable to complete this study;
• Contraindication to DSA examination, severe contrast allergy or absolute contraindication to iodine contrast; women of childbearing age who have a negative pregnancy test but refuse to use effective contraception, are pregnant or breast feeding;
• Those who are unable to complete the study due to psychiatric disorders, cognitive or mood disorders;
• Other patients who, in the opinion of the investigator, are not suitable for enrollment in the study (specify reason).