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NCT Number: NCT07356219

Prognostic Nutritional Index for Predicting Outcomes Following Coronary Artery Bypass Grafting (CABG) Surgery

Coronary artery bypass grafting (CABG) is a major cardiac surgery associated with risks of serious perioperative complications and mortality. Malnutrition and inflammation are known independent risk factors for poor outcomes in patients with coronary artery disease. This retrospective observational study evaluates the Prognostic Nutritional Index (PNI)-a simple score derived from serum albumin and lymphocyte counts-as an objective measure of nutritional and inflammatory status. The research aims to determine how well preoperative PNI and its postoperative changes can predict complications such as acute kidney injury, myocardial infarction, and sternal wound infections in patients undergoing CABG.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

25 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Benha University

Banhā, Al Qalyoubia, 13511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent CABG surgery.
  • Availability of a signed informed consent form before surgery.

Exclusion criteria

  • Other concurrent cardiac surgeries.
  • Presence of malignancy or systemic inflammatory disorders.
  • Active infection or autoimmune disorders.
  • Maintenance on immunosuppressants.
  • Liver disease.
  • Files with missing data.

Treatment and study plan

Prognostic Nutritional Index (PNI)

Diagnostic Test

Calculated using serum albumin (g/L) and total peripheral lymphocyte count.

Neutrophil-to-Lymphocyte Ratio (NLR)

Diagnostic Test

Calculated from peripheral blood counts.

Body Mass Index (BMI)

Diagnostic Test

Calculated from preoperative weight and height.

Primary outcomes

  1. Diagnostic Accuracy of the Prognostic Nutritional Index (PNI) in Predicting Post-CABG Complications.

    Time frame: Approximately 30 days (From surgery through the duration of the hospital/ICU stay.)

    The Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) used to determine the performance of the PNI score in predicting the occurrence of major postoperative complications.

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

The Merits of the Prognostic Nutritional Index for Prediction of the Outcome of Coronary Artery Bypass Grafting Surgery: A Retrospective Observational Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 21, 2026
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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