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OpenTrials
Completed

NCT Number: NCT02946476

Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients

To better understand the public health prognostic impact of noncardiac chronic illnesses, we explored the attributable risk of noncardiac comorbidities on outcomes between heart failure patients with reduced ejection fraction (HFREF) and heart failure patients with preserved ejection fraction (HFpEF) in a large contemporary heart failure (HF) population The adjusted hazard ratio (HR) and the population attributable risk were used to compare the contributions of 15 noncardiac comorbidities to adverse outcome. The comorbidities that contributed to high attributable risk were: anemia, chronic kidney disease, chronic obstructive pulmonary disease, diabetes mellitus, and peripheral artery disease. These findings were similar for HFrEF and HFpEF groups. Interaction analysis confirmed similar results.

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Key information

Conditions

Heart Failure, Diastolic Cardiovascular Diseases Heart Diseases Heart Failure Heart Failure, Systolic

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All consecutive heart failure patients with left ventricular ejction fraction available before or within 3 months from the index visit

Exclusion criteria

  • We excluded all patients who had severe primary left-sided valvular disease

Treatment and study plan

prognostic impact of non cardiac comorbidities

Other

Primary outcomes

  1. overall mortality

    Time frame: 2 years

Secondary outcomes

  1. First all-cause hospitalization

    Time frame: 2 years

  2. Heart Failure hospitalization

    Time frame: 2 years

  3. noncardiovascular hospitalization

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Ospedale Maggiore Di Trieste

Other

Registry information

Official study title

Prevalence and Prognostic Impact of Noncardiac Comorbidities in Heart Failure Outpatients With Preserved and Reduced Ejection Fraction: A Community-Based Study

Acronym: NCC-HF

Important dates

Study start
2009
Primary completion
2013
Study completion
2014
First posted
Oct 27, 2016
Registry last updated
Oct 27, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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