Prognostic Impact of Neopterin on Resumption of Walking After a Fracture of the Upper Neck of the Femur in the Elderly

Hip fracture (HF) is a common condition affecting an estimated 2 million older people worldwide and that number is increasing by 25% each decade as the population continues to grow. HF has serious clinical consequences due to the associated morbidity, the loss of autonomy in individuals generally autonomous before the event. HF has also been shown to be an independent predictor of a new admission to long-term care, representing an unfavorable outcome with annual costs of four billion in the United States alone. Among the avenues aimed at improving the management of HF, the deployment of perioperative geriatric units (UPOG) has improved the prognosis of patients but their implantations are still unfortunately too marginal. It is therefore in the identification of patients most at risk that research must be focused in order to identify the most vulnerable and target interventions. Today, the decision of admission is made early in the course of care, as soon as their arrival to emergencies, and involves discussion between orthopedist, anesthesiologist and geriatrician. This decision is based on criteria that are still very logistical (place or not), clinical (comorbidities, fragility, severity, etc.) but lacks objective information (no predictive signatures) on resilience post HF.

In this context, prognostic biomarkers would have an important role to play in guiding clinicians. The investigators team has shown that neopterin is a biomarker of inflammation and activation of the immune system secreted during HF and whose increased rate has been associated with mortality at one year post HF as well as with functional recovery on D30 after surgery.

The investigators hypothesize that the neopterin measured at the admission of the elderly patient to the emergency ward for HF could improve the prediction of the resumption of walking without major loss of autonomy at D30 after surgery.

The main objective of the study is to assess whether the plasma neopterin concentration can predict the resumption of walking on D30 after surgery, in elderly patients who have undergone surgery as part of a HF.

Inclusion criteria

For both arms:

• age over 75
• affiliated to health insurance system
• written informed consent

For arm 'Fracture':

• patient with a fracture of the upper neck of the femur
• hospitalized in emergency in a 'UPOG' unit

For arm 'control':

• hospitalized patient without any acute clinical event

Exclusion criteria

For both arms:

• polytrauma
• pathological bone or prothesis fracture
• patient affiliated to 'Aide Médical de l'Etat - AME' insurance
• patient with immunosuppressant treatment (including corticotherapy over 5 mg/d)
• patient with active solid cancer or malignant haemopathy
• patient with auto-immune disease
• refusal to participate in research

For arm 'Fracture':

• patient under justice protection measure except tutorship and guardianship

For arm 'control':

• severe neurocognitive disorders (MMS < 15)
• fracture of the upper neck of the femur in the last year
• patient under justice protection measure