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Completed

NCT Number: NCT06325410

Prognostic Factors Influencing the Recurrence Rate and Survival of Patients With Colorectal Cancer: a Single Institution Experience

over the past decade colon cancer has emerged as the second most deadly and the third most common type of cancer in the world with increasing incidence in Egypt due to life style and diet change. some research showed relation between colon cancer recurrence and advanced tumor staging. To investigators knowledge, this is the first time to be done in Zagazig University.

Data was collected from records in a retrospective cohort study

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Disease Attributes Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Rectal Diseases Recurrence

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zagazig University Hospitals

Zagazig, 44519, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients with newly diagnosed colorectal cancer
  • Age > 18 years old
  • recurrent cases of colorectal cancer

Exclusion criteria

  • Pediartric patient less than 18 yr
  • In operable or metastatic cancer colon
  • No other malignancies

Treatment and study plan

resection of colorectal cancer

Procedure

resection of bowel segment and re-anastmosis or stoma formation

Primary outcomes

  1. age

    Time frame: through study completion, an average of 5 years

    age of patients was obtained from medical records

  2. sex

    Time frame: through study completion, an average of 5 years

    sex of patients was obtained from medical records

  3. medical disease

    Time frame: through study completion, an average of 5 years

    co-existing medical disease was obtained from medical records

  4. previous surgery

    Time frame: through study completion, an average of 5 years

    previous surgical history was obtained from medical records

  5. CEA

    Time frame: through study completion, an average of 5 years

    value of carcino-embryonic antigen was recorded

  6. tumor grade

    Time frame: through study completion, an average of 5 years

    tumor grade after resection from pathology report recorded

  7. tumor site

    Time frame: through study completion, an average of 5 years

    tumor site recorded from operative findings

  8. tumor size

    Time frame: through study completion, an average of 5 years

    tumor size was measured by length x width in cm from records

  9. surgical margins of resected tumor

    Time frame: through study completion, an average of 5 years

    safety margins were assessed from pathological examination under microscopy and recorded in pathology reports, it can be free surgical margins ( no tumor cells) or positive surgical margins( presence of tumor cells)

  10. neoadjuvant therapy

    Time frame: through study completion, an average of 5 years

    history of neoadjuvant therapy before surgery from records obtained

  11. adjuvant therapy

    Time frame: through study completion, an average of 5 years

    history of adjuvant therapy post operative obtained from records

  12. diet

    Time frame: through study completion, an average of 5 years

    diet and dietary life style from history

  13. occupation

    Time frame: through study completion, an average of 5 years

    occupation of the patient at time of surgery and if it was changed

  14. family history

    Time frame: through study completion, an average of 5 years

    history taking of family history of cancer disease

  15. type of surgery(laparoscopic or open)

    Time frame: through study completion, an average of 5 years

    type of operation was laparoscopic or open surgery obtained from records

  16. soiling by during surgery

    Time frame: through study completion, an average of 5 years

    by history from records if there was soiling of the field by tumor cells

  17. hand sewen or stappled anastmosis

    Time frame: through study completion, an average of 5 years

    if there was bowel re-anastmosis after surgery, it was done using a stappler or hand sewing sutures. this was obtained from operative data in patient records

  18. post operative complications

    Time frame: through study completion, an average of 5 years

    from records; if there were post operative complication like fecal fistula

  19. site of recurrence

    Time frame: through study completion, an average of 5 years

    site of tumor recurrence was detected

  20. type of resected tumor

    Time frame: through study completion, an average of 5 years

    type of tumor was recorded from pathology reports

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Important dates

Study start
2013
Primary completion
2022
Study completion
2022
First posted
Mar 22, 2024
Registry last updated
Mar 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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