Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection

The purpose of this study was to identify the prognostic factors of affecting pT4bN0M0 colorectal cancer patients, so as to better stratify the prognostic differences among patients with the same stage.

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Key information

Conditions

Colorectal Cancer Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, 100021, China

About this study

Patients with pT4b stage colorectal cancer (CRC) are a complex and special group due to the diversity of infiltrated organs, patients with the same stage often have different prognosis after multivisceral resection (MVR), some important prognostic factors have not been deeply explored, and additional prognostic factors are needed to improve the survival assessment of these patients. In this study, investigators attempted to evaluate the prognostic factors of pT4bN0M0 colorectal cancer, and then stratify the prognosis of such patients to distinguish the survival differences among different patients.

This study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization.The prognostic factors of pT4bN0M0 colorectal cancer patients were analyzed, and the prognostic grading system was constructed to accurately stratify the survival of pT4bN0M0 patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The patient was pathologically diagnosed as colorectal adenocarcinoma.
Patients with pT4bN0M0 colorectal cancer.
Patients with R0 resection.

Exclusion criteria

Patients with distant metastasis.
Patients with R1 or R2 resection.
Patients with lymph node metastasis
Recurrent colorectal cancer.

Treatment and study plan

multivisceral resection

Procedure

The prognostic factors were analyzed for pT4bN0M0 colorectal cancer after multivisceral resection

Primary outcomes

Overall survival

Time frame: The endpoint of the overall survival assessment is the last follow-up or patient death. Follow-up time is up to 72 months.

Overall survival is defined as the time from the surgery to death or last follow-up, regardless of disease recurrence, which was measured in months.
Cancer specific survival

Time frame: The endpoint of the cancer specific survival assessment is the patient death due to cancer. Follow-up time is up to 72 months.

Cancer specific survival is defined as the time from the diagnosis to death due to cancer progression, which was measured in months.

Sponsors and collaborators

Lead sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Other

Registry information

Official study title

Prognosis Stratification for pT4bN0M0 Colorectal Cancer Following Multivisceral Resection: A Multi-institutional Retrospective Analysis

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Nov 3, 2023
Registry last updated: Nov 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed