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OpenTrials
Completed

NCT Number: NCT02312791

Prognosis of Inpatients Evaluated for Palliative Radiotherapy

Understanding patient's prognosis is of utmost importance to determine radiotherapy's indication and dose/ fractionation. The investigators plan to conduct an observational study of prognosis of inpatients evaluated for palliative radiotherapy at a large cancer hospital in Brazil.

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Key information

Conditions

Cancer Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da USP

São Paulo, 01246000, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All inpatients evaluated for palliative radiation therapy at ICESP (Instituto do Cancer do Estado de Sao Paulo)

Exclusion criteria

  • Inpatients evaluated whose intent of treatment is curative
  • Patients who are unwilling to participate in the study or unwilling to sign informed consent

Treatment and study plan

Primary outcomes

  1. Overall Survival

    Time frame: 9 months

    Overall Survival in the studied population

Secondary outcomes

  1. Overall Survival in Each Indication of Palliative Radiotherapy

    Time frame: 3 months and 9 months

    Overall Survival in Each Indication of Palliative Radiotherapy.

    The indication will be as follow:

    • spinal cord compression
    • brain metastases
    • tumor bleeding
    • tumoral mass
    • Oncologic Pain
    • Superior Vena Cava Syndrome/ Airway compression

  2. Overall Survival by Palliative Prognostic Index (PPI)

    Time frame: 3 months and 9 months

    Patients will be divided into 3 subgroups according to the PPI. Survival differences between the different subgroups will be compared and analyzed

  3. Overall Survival by Survival Prognostic Score (SPS)

    Time frame: 3 months and 9 months

    Patients will be divided into 3 subgroups according to the SPS. Survival differences between the different subgroups will be compared and analyzed

  4. Overall Survival by Score Index for Stereotactic Radiosurgery for Brain Metastases (SIR)

    Time frame: 3 months and 9 months

    Patients will brain metastases will be divided into 3 subgroups according to SIR. They will be divided into SIR 0-3; 4-7;8-10. Survival differences between the different subgroups will be compared and analyzed

  5. Positive Predictive Value of PPI

    Time frame: 3 weeks and 6 weeks

    Positive Predictive Value of PPI to predict death at 3 weeks and 6 weeks.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Observational Study of Prognosis of Inpatients Evaluated for Palliative Radiotherapy

Acronym: PROGRAD

Important dates

Study start
2014
Primary completion
2017
Study completion
2019
First posted
Dec 9, 2014
Registry last updated
Jan 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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