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NCT Number: NCT06948565

Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study

Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients.

The following hypotheses will be tested:

* Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014 * Improved access to liver transplantation compared with the literature prior to 2014 * Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.). * Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.

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Key information

Conditions

Cirrhosis Acute on Chronic Liver Failure(ACLF) Acute-On-Chronic Liver Failure Digestive System Diseases Fibrosis Hepatic Insufficiency Intensive Care Medicine Liver Diseases Liver Failure Liver Failure, Acute Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Besançon

Besançon, 25000, France

Location status: Recruiting

Location contact

Delphine Weil Verhoeven, MD PhD

SUB_INVESTIGATOR

Delphine Weil Verhoeven, MD, PhD

CONTACT

[email protected]

+33381669457

Thomas Lelong

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024.

Exclusion criteria

None

Treatment and study plan

observational study

Other

This observational study aims to describe the clinical practices and the outcome of patients admitted in ICU.

Primary outcomes

  1. 28-day survival

    Time frame: 28 days

Secondary outcomes

  1. Phenotype of patients admitted to intensive care

    Time frame: baseline

  2. Overall survival

    Time frame: through study completion

  3. Survival without liver transplantation

    Time frame: 12 months

  4. Proportion of patients listed for liver transplantation

    Time frame: through study completion

  5. number of patients receiving LT

    Time frame: through study completion

  6. Prognostic performance of general and cirrhosis-specific organ failure scores

    Time frame: baseline

  7. Comparison of the characteristics of patients on admission in primary care hospitals and in university hospital.

    Time frame: baseline

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Besancon

Other

Registry information

Acronym: REACIRRHOSE

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Apr 29, 2025
Registry last updated
Aug 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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