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Completed

NCT Number: NCT06289036

Prognosis in Subacute Ischemic Stroke Using Multimodal Imaging

We enrolled patients with subacute IS, associated with moderate-to-severe stenosis of the unilateral cervical internal carotid artery, who underwent 4D ASL. Perfusion levels and collateral circulation were compared between groups with favorable prognosis (modified Rankin scale [mRS] ≤ 2) and poor prognosis (mRS > 2).

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Key information

Conditions

The Levels of Cerebral Perfusion and Collateral Circulation in Patients With Subacute Stroke

Age range

18 year–88 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Confirmed unilateral internal carotid artery/MCA atherosclerotic stenosis/occlusion with a stenosis degree > 50% verified through computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA).
  • Presence of IS or transient ischemic attack (TIA) symptoms in the circulating blood supply area within the preceding 48 h.
  • Asymptomatic patients with no history of IS or TIA in the past 6 months.
  • Performance of 4D ASL tests during hospitalization.

Exclusion criteria

  • Moderate-to-severe stenosis/occlusion of the contralateral internal carotid artery/middle cerebral arteries.
  • Age ≤ 18 years old.
  • Cardioembolic cerebral infarction.
  • Moyamoya disease.
  • Combined or previous cerebral hemorrhage or subarachnoid hemorrhage
  • History of previous cerebral infarction.
  • Claustrophobia or the presence of intracranial metal implants, cochlear implants, or pacemakers.

Treatment and study plan

Primary outcomes

  1. Modified Rankin Scale（mRS） score after 3 months of onset

    Time frame: 3 months

    mRS scores range from 0 to 6, where 0 indicates no symptoms, 3 indicates moderate disability, 4 indicates moderately severe disability, 5 indicates severe disability, and 6 indicates death. Patients were categorized into a good prognosis group (mRS ≤ 2) and a poor prognosis group (mRS > 2).

Sponsors and collaborators

Lead sponsor

The First Hospital of Hebei Medical University

Other

Registry information

Official study title

Predicting Prognosis in Subacute Ischemic Stroke Through Brain Perfusion and Collateral Circulation With Multimodal Imaging

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Mar 1, 2024
Registry last updated
Mar 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.