Prognosis Analysis of Elderly Donor Liver in Liver Transplantation

Based on the follow-up data of elderly donation after cardiac death(DCD) donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

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Key information

Conditions

Liver Transplantation Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Hepatocellular Carcinoma Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Survival

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

About this study

Since the Chinese organ donation system was developed in 2015, donation has been the only source of organs for transplantation in China. Adult patients (age 18 or older) who underwent LT using grafts from deceased donors between January 1st, 2015, and December 31st, 2018, were retrospectively identified using the CLTR, a database and official website for national data gathering. Based on the follow-up data of elderly DCD donor liver transplant recipients from the CLTR, a database and official website for national data gathering. patients who met the enrollment criteria were screened for postoperative complications and survival for statistical analysis to understand the prognosis of patients and analyze the risk factors affecting their prognosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Recipient age ≥ 18 years and < 65 years.
Donor age ≥ 18 years.

Exclusion criteria

Recipient age <18 years or ≥65 years.
Donor age <18 years.
Patients who died within 30 days after transplantation.
Secondary liver transplantation.
Multiple organ transplantation.
Patients with incomplete data or failed follow-up.

Treatment and study plan

age

Other

The study was retrospective and did not involve the application of interventions.

Primary outcomes

Post-operative survival time

Time frame: Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.

Postoperative survival time for patients receiving liver transplantation
Transplanted liver status

Time frame: Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.The functional status of the transplanted liver was recorded during this period.

Postoperative Liver Function in Patients Undergoing Liver Transplantation
Recurrence of the primary disease after surgery

Time frame: The time period between liver transplantation and the initial examination revealing a recurrence of primary disease, or until the end of follow-up on December 31, 2020.whichever came first, assessed up to 72 months.

Recurrence of primary disease in patients who underwent liver transplantation after surgery

Secondary outcomes

Surgery details

Time frame: Intraoperative

Detailed information such as operation time
Post-operative complications in patients who underwent liver transplantation

Time frame: Time from the end of liver transplantation to the patient's death, or the end of follow-up by December 31, 2020. whichever came first, assessed up to 72 months.During this period, all postoperative complications of the patient will be recorded.

Specific details of all post-operative complications in patients who underwent liver transplantation

Sponsors and collaborators

Lead sponsor

First Affiliated Hospital Xi'an Jiaotong University

Other

Registry information

Official study title

Prognosis Analysis of Elderly Donor Liver From Donation After Cardiac Death in Liver Transplantation: a Multicenter Clinical Study

Important dates

Study start: 2015
Primary completion: 2018
Study completion: 2018
First posted: May 2, 2022
Registry last updated: May 2, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed