Progesterone Variation on the Final Day of Oocyte Maturation.

The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retrieval before the ovulation triggering, by evaluating the daily variability of serum progesterone on the day of triggering in healthy women who perform a COS for oocyte donation, through multiple blood samplings.

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Key information

Conditions

Controlled Ovarian Stimulation Circadian Rhythm Oocyte Donors Progesterone Variation on Trigger Day

Age range

18 year–35 year

Sex eligibility

Female

Study type

Observational

Primary location

Salud de la Mujer Dexeus

Barcelona, 08028, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy oocyte donors according to spanish law for oocyte donation
Controlled ovarian stimulation following a flexible antagonist protocol and stimulation with recombinant Follicular stimulating hormone.
Informed consent signed

Exclusion criteria

Detection of luteinizing hormone surge before triggering

Treatment and study plan

Serum progesterone measure

Diagnostic Test

Serum Progesterone will be measured in all donors on the day triggering at 8:00 am, 12:00 p, 16:00 pm and 20:00 pm

Primary outcomes

Progesterone variation among 4 different moments on the day of ovulation triggering

Time frame: Progesterone will be measured 4 times on the day of ovulation triggering, each of them separated 4 hours from the previous one (total 4 samples within 12 hours): blood samples will be obtained at 8:00 am, 12:00 pm, 4:00 pm and 08:00 pm

Measurement of serum Progesterone (ng/ml) in each oocyte donor at 4 different times on the day of ovulation triggering: The primary outcome will be the variation among the 4 progesterone measurements for each patient within the fixed12 hours time (8:00am; 12:00pm; 4:00pm and 8:00pm).

Sponsors and collaborators

Lead sponsor

Fundacion Dexeus

Other

Registry information

Official study title

Progesterone Variation on the Final Day of Oocyte Maturation. A Prospective Cohort Study With Repeated Measurements

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Dec 8, 2017
Registry last updated: Apr 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed