Completed

NCT Number: NCT01058382

Progesterone Support of FET

There have been two very common forms of progesterone administration that have been used during ovulation induction, in vitro fertilization (IVF) and embryo transfers. There are currently no randomized clinical trials to demonstrate which method of progesterone administration is more effective for frozen embryo transfer. We raise the question: Is there a difference between the two accepted methods of progesterone administration, intramuscular and vaginal suppositories, for frozen embryo transfer? Studies for fresh embryo transfer after in vitro fertilization, have demonstrated that there is not a difference between the two methods of progesterone administration. We will evaluate the question for frozen embryo transfer.

Completed

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Key information

Conditions

Frozen Embryo Pregnancy Rate

Age range

20 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Females < 50 years of age
Having frozen embryo transfer at Mayo Clinic
Embryos have been created prior to age 42
Willing to be randomized to either method of progesterone administration

Exclusion criteria

Diagnosis of severe medical illness
Uterine lesions affecting the cavity or endometrium
Uterine anomaly
Presence of hydrosalpinx
Extreme difficulty with embryo transfer

Treatment and study plan

Progesterone Vaginal Suppositories

Drug

Progesterone Vaginal Suppositories 200 mg three times daily for 10 weeks following embryo transfer

Intramuscular Progesterone-in-Oil

Drug

Progesterone-in-Oil 50 mg IM once daily for 10 weeks following embryo transfer

Primary outcomes

Clinical Pregnancy Rate

Time frame: 3 years

Secondary outcomes

Implantation rate

Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Charles Coddington

Other

Registry information

Official study title

Progesterone Support for Frozen Embryo Transfer: Intramuscular Versus Vaginal Suppository - A Prospective, Randomized, Controlled Trial

Acronym: FETProg

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: Jan 28, 2010
Registry last updated: May 10, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.