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Completed

NCT Number: NCT01536821

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alberta, Edmonton, Alberta, Canada

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About this study

Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:

  • Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
  • Be given a brief standard neurological examination.
  • Be given a scratch and sniff smell identification test.
  • Be asked to give a sample of approximately 2 tablespoons of blood.
  • Be asked to give a urine sample of approximately 1 tablespoon of urine.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Positive for a LRRK2 mutation

Treatment and study plan

Primary outcomes

  1. Observation and biological specimen collection

    Time frame: 1 time

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

  • Michael J. Fox Foundation for Parkinson's Research

Registry information

Official study title

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study

Acronym: PROGENI

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Feb 22, 2012
Registry last updated
Dec 16, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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