Profile and Regulatory Network of Exercise in Improving Metabolic Phenotypes of Patients With Prediabetes

Inclusion criteria

• Han Chinese
• 5.6 mmol/L≤fasting blood glucose<7 mmol/L, and/or 7.8 mmol/L≤2h-postload glucose<11.1mmol/L, and/or 5.7% ≤HbA1c<6.5% without anti-hyperglycemic medicine treatment
• Voluntary participation and provide informed consent

Exclusion criteria

• Participated in any clinical study in relation to weight-loss in the past 1 year
• Had a weight change of more than 10% present weight in the past 1 year
• Had a drug usage not suitable for this study in the past 3 months, such as hormone drug, orlistat, metformin, GLP-1 receptor agonists, lipid-lowering agents, liver protection drug, etc
• Presence of diseases influencing glucose and lipid metabolism ,such as hyperthyroidism, hypothyroidism, Cushing syndrome, etc
• Poorly controlled blood pressure: systolic blood pressure≥180mmHg, and/or diastolic blood pressure≥100mmHg
• Presence of serious heart, liver, kidney or systemic diseases
• Presence of skeletal and muscular diseases which make it difficult to exercise
• Received any kind of surgery in the past 1 year
• COVID-19 positive or recovery from COVID-19 within 4 weeks
• Presence of eating disorders or have a history of eating disorders
• Presence of sleep disorders
• Work in disrupted circadian rhythms
• Pregnancy and breastfeeding women