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NCT Number: NCT05238285

Production of Nonverbal Acoustic Signals and Resulting Physiological Responses

Like many other animals, humans produce nonverbal vocal signals including screams, grunts, roars, cries and laughter across a variety of contexts. However, despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal signals remain little studied and poorly understood in humans.Our studies aim to improve our understanding of the nature and function of non-verbal signals.

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Key information

Conditions

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Universitaire de Saint-Etienne

Saint-Etienne, 42055, France

Location status: Recruiting

Location contact

David REBY, MDPHD

SUB_INVESTIGATOR

Nicolas MATHEVON, MDPHD

SUB_INVESTIGATOR

Roland PEYRON, MD PhD

PRINCIPAL_INVESTIGATOR

About this study

Like many other animals, humans produce nonverbal vocal signals including screams, grunts, roars, cries and laughter across a variety of contexts. Many of these signals (such as cries) are already produced at birth and likely serve a number of important biological and social functions. In addition, human speech is characterised by nonlinguistic acoustic parameters (such as pitch, formant frequencies, and nonlinear phenomena) that are known to correlate with biologically important traits of the vocalizer.

However, despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal signals remain little studied and poorly understood in humans.

Theses studies aim to improve the understanding of the nature and function of non-verbal signals. Thus, this study is part of a long-term research project in which investigators are trying to clarify the information contained in the acoustic structure of human non-verbal signals, and to investigate the factors influencing their production.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participant should be affiliated or entitled to a social security scheme

Exclusion criteria

  • Pregnant women
  • Voice production disorders
  • Hearing impairment, speech production disorders or major health problems.
  • Chronic smoker (more than 10 cigarettes per day)

Treatment and study plan

Production of vocal sounds

Behavioral

Participants will be asked to produce vocal sounds of different nature according to the non-verbal parameters of interest for the given study.

For example, they can read a script containing vowels ('a', 'e', 'i', 'o', 'u'), short sentences ('hello, how are you'), longer passages of standardised reading texts, and can also be asked to speak freely about any topic ('freedom of speech'). They can be asked to play a role or to imitate a particular emotional state. For example, "imagine that you have just been told that you have won a million euros in the lottery. Produce a vocalisation to express your excitement" or "talk to your dog your dog by imagining that he has done a negative action and then do the same thing by imagining that this time imagining that the action was positive".

Primary outcomes

  1. Vocal analysis

    Time frame: During the vocal production

    Participants will receive instructions on what to say or what type of non-verbal vocalisation to produce during the manipulation.

    The vocalisations thus produced by the participants will be systematically recorded and analysed using software adapted to acoustic analysis

    Measurement of acoustic variables such as fundamental frequency (pitch), vocal tract resonances (formants) and vocal disturbances (jitter, shimmer), the nonlinearities and chaotic/noise properties of vocalisations

Secondary outcomes

  1. Heart rate (bpm)

    Time frame: During the vocal production

  2. Skin conductance (Siemens)

    Time frame: During the vocal production

  3. Skin temperature (°C)

    Time frame: During the vocal production

  4. Nociception Level Index (NOL)

    Time frame: During the vocal production

    A non-invasive finger probe, containing four sensors, will be placed on the on the index finger of the participants.

  5. Pupillary diameter (millimeter)

    Time frame: During the vocal production

    Using a high resolution binocular for automated pupil diameter measurement with an infrared camera

Study contacts

Contact information is provided by the study sponsor or research team.

Nicolas MATHEVON, PhD

CONTACT

[email protected]

04 77 48 50 22 ext. +33

ROLAND PEYRON, MDPhD

CONTACT

[email protected]

(0)477127805 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Collaborators

  • University of Lyon

Registry information

Acronym: SINOVE-PRO

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Feb 14, 2022
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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