Procedural Complications and Long-Term Mortality in Complex Coronary Interventions

The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described. This study aimed to assess the association between non-fatal intraprocedural complications and late mortality after complex coronary PCI.

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Key information

Conditions

Complex Coronary Artery Disease Cardiovascular Diseases Death Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

İstanbul Mehmet Akif Ersoy Thoracic And Cardiovascular Surgery Training and Research Hospital

Istanbul, 33484, Turkey (Türkiye)

Location status: Recruiting

Location contact

Ahmet Güner

CONTACT

[email protected]

05056533335

About this study

Complex coronary lesions include chronic total occlusion, osteal epicardial lesions, long (diffuse) coronary disease, severe calcific lesions, true bifurcation disease, left main coronary lesion, lesions with severe thrombus, and in-stent restenosis. Non-fatal intraprocedural complications included abrupt occlusion, worsening of thrombolysis in myocardial infarction (TIMI) flow grade (TIMI < 3), major dissection (greater than type B), occurrence of thrombus formation, perforation of the main vessel or side branch, malignant arrhythmias, stroke/transient ischemic attack, and non-coronary major bleeding.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with complex coronary disease
Aged 18-85 years

Exclusion criteria

Patients diagnosed with cardiogenic shock
Coronary lesions with non-complex features
Percutaneous coronary intervention with a bare metal stent
Patient life expectancy <1 year
Known relevant allergies
Absence of all medical records
Patients with early discontinuation of dual antiplatelet therapy

Treatment and study plan

Primary outcomes

Death

Time frame: up to 60 months

All cause death

Sponsors and collaborators

Lead sponsor

Istanbul Mehmet Akif Ersoy Educational and Training Hospital

Other Gov

Collaborators

Ankara Bilkent Sehir Hastanesi
Ankara Etlik City Hospital
Bagcilar Training and Research Hospital
Bursa City Hospital
Bursa Yuksek Ihtisas Training and Research Hospital
Cigli Regional Training Hospital
Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Ege University
Istanbul Training and Research Hospital
Istanbul University - Cerrahpasa
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Kocaeli University
Sisli Hamidiye Etfal Training and Research Hospital
Trakya University
University of Yalova
Van Training and Research Hospital

Registry information

Official study title

The Impact of Procedural Complications on Long-Term Mortality in Complex Coronary Interventions: The Multicenter COMPLEX-ANATOLIA Study

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Oct 2, 2025
Registry last updated: Jul 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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