Probiotics for Constipation Relief in Adults

Inclusion criteria

• Adults aged 18-65 years;
• Individuals diagnosed with constipation, defined as fewer than 3 bowel movements per week and/or Bristol Stool Form Scale (BSFS) types 1-2;
• Able and willing to comply with all study procedures and complete the study;
• Provided written informed consent prior to participation;
• Participants (including males) must have no intention of conception from 14 days before screening until 6 months after study completion and agree to use effective contraception.

Exclusion criteria

• Recent use of products with similar effects that may interfere with study outcomes; Significant dietary changes during the study period;
• History of severe allergy or immunodeficiency;
• Pregnant or breastfeeding women, or those planning pregnancy;
• Presence of serious systemic diseases (e.g., cardiovascular, pulmonary, hepatic, renal, endocrine, or malignant conditions);
• Use of antibiotics within the past 2 weeks;
• Individuals with severe psychiatric or neurological disorders;
• Poor compliance, including failure to take the study product or attend scheduled visits;
• Any other condition deemed unsuitable by the investigator.