Probiotic Treatment of Orthodontic Patients

Inclusion criteria

• Generally healthy males and females ≥ 10 years of age.
• Able to read and receive a copy of the signed informed consent form.
• Have at least 20 natural teeth.
• Have been undergoing orthodontic treatment with fixed orthodontic appliances in the upper and/or lower jaw > 6 months.
• An average plaque score of > 2 according to the Modified Orthodontic Plaque Index (MOPI) at the screening appointment.

Exclusion criteria

• Significant oral soft tissue pathology based on a visual examination.
• History of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or chewing gum or their ingredients.
• History of allergies to milk proteins.
• History of allergies towards probiotics.
• Self-reported as pregnant or nursing.
• Self-reported serious medical conditions.
• Antibiotic or anti-inflammatory medication within 30 days of screening visit.
• Acute sinusitis or severe oral-pharyngeal infections.
• Smoker.