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OpenTrials
Completed

NCT Number: NCT05350176

Probiotic Supplementation in Sport Performance and Gut Damage

This study will be performed with the aim to evaluate the effects of probiotic supplementation on sport performance and gut damage. Participants will be divided into two groups, placebo and experimental group. With the purpose to assess the effects of probiotics on the gut damage, a strenuous exercise session will be performed, and then blood samples will be taken to observe the variation of the selected intestinal damage marker. 24 hours after this strenuous session, performance tests will be performed. After the 4 weeks of supplementation, the same procedure will be followed to evaluate the effect of probiotics.

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Key information

Conditions

Sport Performance Gut Damage

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

CrossFit Bikain

Vitoria-Gasteiz, Alava, 01015, Spain

About this study

One week before the initiation of the study participants will be required to avoid consuming drugs, alcohol, cigarettes, probiotics, and any other food or liquid which could modify gut microbiota composition. For the baseline values, height, weight and sports performance test, of the participants will be collected. The same day, a strenuous exercise session will be performed in order to observe the variation of the intestinal damage marker (blood sample extraction just after finishing the strenous exercise session). 24 hours after that session sport performance tests will be conducted. Participants will then be randomly divided into two groups, one of which will take one probiotic capsule per day containing 10 billion colony-forming units (CFU) of Lactobacillus plantarum, and the other group will take one placebo capsule per day consisting of dextrose. The supplementation period will last 4 weeks.

After the supplementation period, the same process will be followed, with the same strenuous exercise session and immediate blood sampling to determine the effects of probiotics on the intestinal damage caused by exercise. 24 hours later, performance tests will be conducted to assess the effects of probiotics on sport performance.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • No injuries
  • 1 year of CrossFit practicing experience

Exclusion criteria

  • Drug, alcohol, cigarettes, probiotic intake
  • Injuries

Treatment and study plan

Probiotic

Dietary Supplement

Probiotic capsules will be composed of 10 billion CFU of Lactobacillus plantarum.

Placebo

Dietary Supplement

Capsules containing dextrose (1 capsule per day)

Primary outcomes

  1. Intestinal-fatty acid-binding protein

    Time frame: 0-10 minutes after strenuous exercise blood samples will be extracted

    Gut damage marker

  2. Counter movement jump test

    Time frame: 24 hours after strenuous training session. First test to be performed

    Jumping test

  3. Running Based Anaerobic Sprint Test

    Time frame: 24 hours after strenuous training session. Second test to be performed

    Running test

  4. YO YO Intermittent Recovery Level test 1

    Time frame: 24 hours after strenuous training session. Third test to be performed

    aerobic test

Sponsors and collaborators

Lead sponsor

University of the Basque Country (UPV/EHU)

Other

Registry information

Official study title

Effects of Probiotic Supplementation on Sport Performance and Gut Damage in CrossFit

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Apr 28, 2022
Registry last updated
Jan 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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