Probiotic Sport Study

We investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise.

Hypotheses (H1):

* Supplementation has an influence on oxidative stress parameters before and post exercise * Supplementation has an influence on parameters of endotoxemia and inflammation before and post exercise * Strenuous exercise has an influence on parameters of oxidative stress, inflammation and endotoxemia

Completed

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Key information

Conditions

Oxidative Stress Bacteremia Endotoxemia Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome Toxemia

Age range

30 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of Graz

Graz, 8010, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

trained men
30 - 45 years
non-smokers
4wk wash out of all dietary supplements

Exclusion criteria

untrained people (VO2max < 55 ml x kg-1)
female
all people not matching this age group
smokers
all men taking dietary supplements
all men that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure > 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..)
all people that are not adjudged as "Healthy"

Treatment and study plan

probiotic-based dietary supplement

Dietary Supplement

24 trained men receive a probiotic-based dietary supplement for 16 weeks. Dosage 3x 10-9 per day

Other names: active group

Placebo

Dietary Supplement

24 trained men receive a placebo for 16 weeks with same dosage compared to active group

Other names: passive group

Primary outcomes

markers of oxidative stress, endotoxemia and inflammation

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Green Beat

Other

Registry information

Official study title

Impact of Supplementation With Probiotics on Exercise-induced Oxidative Stress and Endotoxemia in Trained Men

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2012
First posted: Nov 18, 2011
Registry last updated: Apr 10, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed