Probiotic Chewables in Allergic Rhinoconjunctivitis Patients

Inclusion criteria

• Adults aged 18 at the time of registration;
• Seasonal allergic rhinoconjunctivitis (AR) in the context of grass pollen allergy diagnosed on the basis of anamnesis cfr. ARIA guidelines and positive skin prick test and / or immunocap assay;
• Positive skin prick test (SPT) for grass pollen and / or the presence of specific IgE for grass pollen, confirmed by a medical specialist, measured at the start of the study: Soluprick SQ Phleum pratense pollen 10 HEP - ALK and / or IgE specific immunocap assay Phleum pratense (timothy grass) (g6);
• Body Mass Index in the range of 19-32 kg / m2;
• Instructed during screening and agreed not to use other probiotic products outside of the study during the study period;
• Signed the consent form.

Exclusion criteria

• Antibiotic use at baseline and during the study;
• Pregnant women;
• Unstable / uncontrolled asthma (to be determined by investigator-physician);
• Sensitization to dust mites
• History of probiotic use in the past two weeks;
• Current diagnosis of cancer or immunosuppressive therapy within the past 6 months;
• Abnormalities of the oral mucosa;
• Acute and chronic infectious and inflammatory upper airway diseases (eg acute / chronic rhinosinusitis cfr. EPOS guidelines);
• Clinically significant bleeding disorder;
• Any other medical condition that, in the principal investigator's opinion, warrants exclusion from the trial;
• History of regular use (> 3 days out of 7) of tobacco products within the previous two weeks