NCT Number: NCT07356869
This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.
Interested in participating?
Request Info6 year–12 year
All sexes
Interventional
Not applicable
Cairo, 11651, Egypt
Location status: Recruiting
Adel F Hussein, MD
SUB_INVESTIGATOR
Alsayed E Mekky, MD
SUB_INVESTIGATOR
Mohamed O Abdelrazik, MBBCH
CONTACT
Ramy S Khairallah, MD
SUB_INVESTIGATOR
Dental caries remains one of the most prevalent chronic infectious diseases among Egyptian schoolchildren, with Streptococcus mutans (S. mutans) playing a primary etiological role due to its acidogenic and aciduric properties, which contribute to enamel demineralization and plaque formation.
Ethyl Lauroyl Arginate (LAE), a cationic surfactant derived from lauric acid and arginine, has demonstrated potent bactericidal activity against cariogenic organisms, including S. mutans, while also reducing biofilm formation and preserving oral microbiome balance.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Patients will be receive probiotic mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.
Patients will be treated with ethyl lauroyl arginate mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.
Patients will receive professional prophylaxis (scaling + polishing) at baseline and will use only regular toothpaste twice daily, with no adjunctive mouthwashes over 28 days.
Time frame: 28 days post-intervention
S. mutans count will be measured at baseline (0 day) and post-intervention (28 days).
Time frame: 28 days post-intervention
The plaque index score is classified as:
Plaque index score will be measured at baseline (0 day) and post-intervention (28 days).
Time frame: 28 days post-intervention
Salivary pH measurements will be carried out by pH strips or pH meter.
Contact information is provided by the study sponsor or research team.
Al-Azhar University
Other
Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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