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NCT Number: NCT07460583

ProActive Athlete Heart Program: Proposal for Cardiac Risk Screening in Former High-Intensity Athletes

AI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes

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Key information

Conditions

Coronary Atherosclerosis Due to Calcified Coronary Lesion

Age range

30 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baylor Scott & White The Heart Hospital- Plano

Plano, Texas, 75093, United States

Location contact

Bonnie Ostergren

CONTACT

[email protected]

469-814-4181

About this study

A prospective, interventional, single-center study to determine the prevalence and characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Former professional or collegiate high-intensity athletes (e.g., NFL alumni, Division I athletes, or equivalent competitive-level participants).
  • Age ≥30 years

Exclusion criteria

  • eGFR <40 mL/min/1.73 m²
  • Known iodinated contrast allergy
  • Weight >450 lbs. (scanner table limit)
  • Inability to hold breath >10 seconds
  • Uncontrolled arrhythmia
  • Contraindication to beta-blocker, Calcium Channel Blockers and nitroglycerin
  • Taking part in another research study that has not given their permission to participate in this one
  • Pregnancy

Treatment and study plan

Coronary CTA

Device

The Coronary CTA will be performed for each participant. These images will be analyzed using AI-software to assess plaque quantification and an ischemia analysis, if necessary.

Primary outcomes

  1. Prevalence of Coronary Atherosclerosis

    Time frame: At CCTA assessment

    The primary outcome is to determine the prevalence of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

  2. Coronary Atherosclerosis Characteristics

    Time frame: At CCTA Assessment

    Determine the characteristics (burden, composition, risk features) of coronary atherosclerosis in former high-intensity athletes using AI-guided software to analyze a CCTA.

Secondary outcomes

  1. Plaque Burden

    Time frame: Day of CCTA and biomarker collection

    The secondary outcome is to correlate plaque burden with biomarkers (Lipid panel, HbA1c).

Study contacts

Contact information is provided by the study sponsor or research team.

Bonnie Ostergren

CONTACT

[email protected]

469-814-4181

Sponsors and collaborators

Lead sponsor

Baylor Research Institute

Other

Collaborators

  • Cleerly, Inc.

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 10, 2026
Registry last updated
May 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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