Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation

Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.

Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

≥ 18 and ≤ 30 years of age
Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
Elicitable N20 sensory evoked potential

Exclusion criteria

History of neurological disease
Seizure within the past 2 years
Currently taking epileptogenic medication
Peripheral neuropathy
Cognitive impairment and/or major psychiatric disorder
Metal in the head (dental permitted)
Pacemaker or other indwelling devices
Pregnancy

Treatment and study plan

Transcranial Magnetic Stimulation (Magstim)

Device

Other names: TMS, Magstim

Primary outcomes

Change from baseline peak-to-peak amplitude of motor evoked potential

Time frame: Immediately before and within 60 minutes following intervention

Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The peak-to-peak amplitude of the EMG response will be measured.
Change from baseline resting motor threshold

Time frame: Immediately before and within 60 minutes following intervention

Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The lowest stimulator output needed to elicit a consistent response will be recorded.

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Registry information

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2017
First posted: Dec 2, 2015
Registry last updated: Nov 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed