Primary Obstructive Megaureter Management in Eastern Interregional Area

Congenital obstructive megaureter is a urinary malformation affecting the ureterovesical junction and causing obstruction to the flow of urine. It is the second most common cause of hydronephrosis. This malformation affects four times more boys than girls and is bilateral in 25% of cases. It is also associated with contralateral renal dysplasia in 15% of cases. The obstruction is linked to aperistalsis and hypertrophy of the circular muscle bundles and increased collagen 1 level. This malformation is accessible to antenatal screening from the second trimester. It falls within the scope of CAKUT and requires regular monitoring. Indeed, this uropathy can cause repeated pyelonephritis, kidney scarring and affected kidney function.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Congenital Obstructive Megaureter Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hydronephrosis Kidney Diseases Male Urogenital Diseases Urogenital Diseases Urologic Diseases

Age range

1 year–17 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Chirurgie pédiatrique - CHU de Strasbourg - France

Strasbourg, 67091, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Minor patient (from 1 to 17 years old)
Patient treated between January 2010 and December 2017 in one of the participating centers for an obstructive congenital mega-ureter
Subject (and/or his parental authority) not having expressed, after information, his opposition to the reuse of his data for the purposes of this research

Exclusion criteria

Subject (and/or his parental authority) having expressed, after information, his opposition to the reuse of his data for the purposes of this research

Treatment and study plan

Primary outcomes

Determine over the past seven years, the operability factors of patients aged 0 to 5 years regardless of the surgical technique used

Time frame: Files analysed retrospectively from January 01, 2010 to December 31, 2017 will be examined

This study aims to make a retrospective inventory and perspective on the management of congenital obstructive mega ureter

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Primary Obstructive Megaureter Management in Eastern Interregional Area : Current Status and Perspectives

Acronym: POMME

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Dec 6, 2022
Registry last updated: Dec 8, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed