Prevention of Postoperative Atrial Fibrillation

The primary aim of this study is to determine the safest and most effective therapeutic strategy to decrease the incidence of postoperative atrial fibrillation following cardiac surgery in an era with shorter ICU and hospital length of stay. A secondary goal is to evaluate the length of hospital stay associated with each treatment strategy.

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Key information

Conditions

Postoperative Atrial Fibrillation

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

George Washington University, Washington D.C., District of Columbia, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age > or = to 18 years
sinus rhythm
undergoing either coronary artery bypass graft surgery (CABG), valvular heart surgery or a combined procedure

Exclusion criteria

received a class-I or class-III antiarrhythmic agent in the past six months
had second or third degree heart block
had a resting heart rate of less than 50 beats per minute
had a systolic blood pressure less than 100 mmHg
had severe asthma or severe chronic obstructive pulmonary disease
had uncontrolled heart failure
had a serum aspartate aminotransferase or alanine aminotransferase concentration greater than four times the upper limit of normal

Treatment and study plan

Primary outcomes

occurrence of atrial fibrillation

Time frame: postoperative day 0-day of discharge (an average of 5 days)

The primary endpoint of this study was also the occurrence of atrial fibrillation for any length of time requiring treatment as a result of symptoms or hemodynamic compromise.
occurrence of atrial fibrillation

Time frame: postoperative day 0-day of discharge (an average of 5 days)

The primary endpoint of this study was the occurrence of atrial fibrillation lasting longer than five minutes

Secondary outcomes

length of stay

Time frame: participants will be followed for the duration of hospital stay, an expected average of 5 days

The secondary endpoint was the length of hospital stay after surgery.

Sponsors and collaborators

Lead sponsor

George Washington University

Other

Registry information

Official study title

A New Therapeutic Strategy to Reduce the Incidence of Postoperative Atrial Fibrillation

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Dec 5, 2012
Registry last updated: Oct 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed