Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions

There is a pressing need to find effective strategies for the prevention of contrast induced nephropathy in patients with advanced renal dysfunction. The current study was designed to assess the efficacy of a new protocol for preventing contrast induced nephropathy in patients with advanced renal dysfunction undergoing coronary interventions

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Key information

Conditions

Kidney Disease, Chronic Cardiovascular Diseases Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Ischemic Heart Disease Kidney Diseases Male Urogenital Diseases Myocardial Ischemia Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Meir Medical Center

Kfar Saba, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with estimated glomerular filtration rate<45ml/min undergoing coronary angiography due to one of the following indications in accordance with the 2014 guidelines:

Elective coronary angiography due to symptoms suggestive for angina with a positive non-invasive ischemia assessment of ≥10% of left ventricle.
Non ST-elevation acute coronary syndrome with a GRACE score>110

Exclusion criteria

Patients on dialysis or those planned for dialysis in the next 3 months.
Patients with ST-elevation myocardial infarction
No symptoms or signs of heart failure
Treatment with IV diuretics during the 48 hours prior to enrolment
Patients with acute renal failure (Creatinine raise of at least 0.3mg/dl from )baseline
Patients post coronary artery bypass surgery

Treatment and study plan

Percutaneous coronary intervention

Procedure

Patients planned for coronary angiography or percutaneous coronary intervention will be managed using a protocol that allows us to use minimal volumes of contrast dye

Primary outcomes

Changes in glomerular filtration rate following coronary angiography or intervention

Time frame: 24 and 48 hours post procedure

Significant changes are defined as a reduction ≥25% in glomerular filtration rate

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Official study title

The Efficacy of a New Protocol for Preventing Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: Jun 10, 2015
Registry last updated: Nov 22, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed