Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea

Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher hospital costs. Among the main mechanisms involved, excessive sympathetic activation, oxidative stress and inflammation are fundamental elements in the pathophysiology of obstructive sleep apnea. Objectives. To evaluate the effects of continuous positive airway pressure (CPAP) in reduction of atrial fibrillation after CABG in patients with obstructive sleep apnea. Methodological procedures: A multicenter randomized controlled study to compare the incidence of atrial fibrillation between the intervention group and the control group, both monitored seven days with Holter.

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Key information

Conditions

Atrial Fibrillation Apnea Arrhythmias, Cardiac Cardiovascular Diseases Coronary Artery Bypass Grafting Dyssomnias Heart Diseases Nervous System Diseases Obstructive Sleep Apnea Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

30 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Instituto de Medicina Integral Prof Fernando Figueira - Imip, Recife, Pernambuco, Brazil

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

apnea-hypopnea index > 15 events/hour

Exclusion criteria

ejection fraction < 45%
chronic atrial fibrillation
periprocedural instability (haemodynamic, neurological)

Treatment and study plan

CPAP

Device

patients will receive CPAP therapy with Auto-CPAP

Primary outcomes

atrial fibrillation

Time frame: first 7 days after CABG

will be verified by holter monitoring

Sponsors and collaborators

Lead sponsor

Rodrigo Pinto Pedrosa

Other

Registry information

Official study title

Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea: a Multicenter Study

Acronym: PAFOS

Important dates

Study start: 2016
Primary completion: 2019
Study completion: 2019
First posted: Apr 13, 2016
Registry last updated: Dec 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed