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NCT Number: NCT06848686

Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients

HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based "Prevention Ambassadors" (PA) intervention to promote HIV testing and service uptake among PWUD via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWUD). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWUD in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.

Recruiting

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Key information

Conditions

HIV

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

San Diego State University

San Diego, California, 92182, United States

Location status: Recruiting

Location contact

Heather Pines

CONTACT

[email protected]

619-594-2481

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Index Participant Inclusion Criteria:

  • Being greater than or equal to 18 years old
  • Reporting drug use (past month)
  • Having other people who use drugs (PWUD) in one's social network
  • Being willing to talk about HIV testing and services with at least 2 PWUD in their networks and attempt to refer them to the study
  • Speaking English fluently

Peer-Recruit Participant Inclusion Criteria:

  • Being greater than or equal to 18 years old
  • Reporting drug use (past 3 months)
  • Being recruited by an index participant (evidenced by presenting the coupon used to recruit them)
  • Speaking English fluently

Exclusion criteria

  • Persons who participated in formative study activities related to the development of the PA intervention will not be eligible to participate.

Treatment and study plan

Prevention Ambassadors

Behavioral

Delivery of prevention supplies and information on local services plus training to build the capacity of PWUD to distribute HIV self-testing (HIVST) kits with information and referrals to other PWUD in their social networks to promote HIV testing and HIV service engagement among PWUD.

SSP Standard of Care

Behavioral

Delivery of prevention supplies and information on local services.

Primary outcomes

  1. HIV testing (past 3 months)

    Time frame: 3-month follow-up

    Self-reported via survey and abstracted from medical record

  2. Linkage to PrEP/HIV care (past 3 months)

    Time frame: 3-month follow-up

    Self-reported via survey and abstracted from medical record

  3. PrEP/ART uptake (past 3 months)

    Time frame: 3-month follow-up

    Self-reported via survey and abstracted from medical record

Secondary outcomes

  1. PA Acceptability (Peer-Recruit Participants)

    Time frame: Baseline

    Self-reported via survey

  2. PA Acceptability (Index Participants)

    Time frame: 3-month follow-up

    Self-reported via survey

  3. PA Feasibility (Peer-Recruit Participants)

    Time frame: Baseline

    Self-reported via survey

  4. PA Feasibility (Index Participants)

    Time frame: 3-month follow-up

    Self-reported via survey

Study contacts

Contact information is provided by the study sponsor or research team.

Heather Pines

CONTACT

[email protected]

619-594-2481

Sponsors and collaborators

Lead sponsor

San Diego State University

Other

Collaborators

  • Dap Health
  • National Institute on Drug Abuse (NIDA)
  • University of California, Riverside
  • University of California, San Diego

Registry information

Official study title

Prevention Ambassadors: an HIV Self-testing Intervention to Promote HIV Service Engagement in the Networks of SSP Clients

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Feb 27, 2025
Registry last updated
Jan 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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