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Recruiting

NCT Number: NCT04947098

Prevent Cancer- Greenville

Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. If subjects are found to be at high risk for developing a disease, they will be sent to a healthcare provider for further care.

Recruiting

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Key information

Conditions

Cancer High-Risk Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Prisma Health-Upstate

Greenville, South Carolina, 29605, United States

Location status: Recruiting

Location contact

Joe Stephenson, MD

PRINCIPAL_INVESTIGATOR

Patricia Wilson, MSN Ed. OCN ONNCG

CONTACT

[email protected]

864-455-4897

About this study

Participants' personal history, lifestyle behaviors and blood, urine, and cheek swab specimens will be used to detect changes or trends that might put them at risk for developing cancer. Some individuals may be at an above average risk of cancer due to lifestyle, family background, personal genetic makeup, or environmental exposures. This will be determined by a process called risk stratification. Risk stratification involves looking at all health-related aspects of a person, determining their individualized risk through screening, and educating them on measures to reduce potential for disease. Participants will complete a yearly health assessment which includes measurements for nutrition, activity, individual risk factors and body composition, including weight height and a special scale which measures fluid and fat.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older

Treatment and study plan

Primary outcomes

  1. Assess changes in nutrition by nutrition questionnaire

    Time frame: Yearly follow up for 10 years

    Nutrition will be assessed yearly by a questionnaire based on nutrition recommendations from the American Institute for Cancer Research and the U.S. Department of Health and Human Services.

  2. Assess changes in physical activity by physical activity questionnaire

    Time frame: Yearly follow up for 10 years

    Physical activity will be assessed yearly a questionnaire based on physical activity recommendations from the U.S. Department of Health and Human Services.

  3. Assess changes in smoking habits

    Time frame: Yearly follow up for 10 years

    Participants will be educated on healthy lifestyle habits and smoking habits will be assessed yearly.

  4. Assess changes in alcohol use

    Time frame: Yearly follow up for 10 years

    Participants will be educated on healthy lifestyle habits and alcohol use will be assessed yearly.

  5. Assess hereditary risk through family history review

    Time frame: Yearly follow up for 10 years

    Each participant's family history will be reviewed to make recommendations for screening or genetic testing based on National Comprehensive Cancer Network guidelines.

  6. Assess lifetime breast cancer risk through the Tyrer-Cuzick version 8 breast risk evaluation tool

    Time frame: Yearly follow up for 10 years

    Participants' breast cancer risk will be assessed using the Tyrer-Cuzick breast cancer risk model. Participants will be referred to appropriate clinics if lifetime risk is greater than 20 percent.

  7. Assess 5- year breast cancer risk through the GAIL breast risk evaluation tool

    Time frame: Yearly follow up for 10 years

    Participants' breast cancer risk will be assessed using the National Cancer Institute's GAIL model. Participants will be referred to appropriate clinics if GAIL 5 year risk is greater than 1.7 percent.

  8. Early detection of malignancies through screening

    Time frame: Yearly follow up for 10 years

    Participants will be educated on screening recommendations by the American Cancer Society. Malignancies will be recorded yearly if found by recommended screenings.

  9. Assess changes in fat mass by SOZO measurements

    Time frame: Yearly follow up for 10 years

    Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure fat mass.

  10. Assess changes in muscle mass by SOZO measurements

    Time frame: Yearly follow up for 10 years

    Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure muscle mass.

Secondary outcomes

  1. Assess changes in quality of life by the 5-level EuroQol-5D version (EQ-5D-5L) questionnaire

    Time frame: Yearly follow up for 10 years

    Quality of life will be assessed yearly by the EQ-5D-5L questionnaire. Participants' will self-report their health on a scale numbered 0-100. 100 means the best health you can imagine and 0 means the worst health you can imagine.

Study contacts

Contact information is provided by the study sponsor or research team.

Patricia Wilson, MSN Ed. OCN ONNCG

CONTACT

[email protected]

864-455-4897

Sponsors and collaborators

Lead sponsor

Prisma Health-Upstate

Other

Registry information

Official study title

Prevent Cancer-Greenville: A Center for Cancer Prevention and Wellness Research Project

Acronym: CCPW

Important dates

Study start
2018
Primary completion
2028
Study completion
2029
First posted
Jul 1, 2021
Registry last updated
Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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